Republished: Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note

Michal Zawadzki, Jerzy Walecki, Boguslaw Kostkiewicz, Kacper Kostyra, Monica Pearl, Meiyappan Solaiyappan, Piotr Walczak, Miroslaw Janowski

Research output: Contribution to journalArticle

Abstract

Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.

Original languageEnglish (US)
JournalJournal of neurointerventional surgery
DOIs
StatePublished - Jan 1 2019

Fingerprint

Brain Neoplasms
Brain
Pharmaceutical Preparations
Intra Arterial Infusions
Butterflies
Drug Delivery Systems
Glioblastoma
Blood-Brain Barrier
X-Rays
Therapeutics
Bevacizumab

Keywords

  • brain
  • intervention
  • malignant
  • MRI
  • technique

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Republished : Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note. / Zawadzki, Michal; Walecki, Jerzy; Kostkiewicz, Boguslaw; Kostyra, Kacper; Pearl, Monica; Solaiyappan, Meiyappan; Walczak, Piotr; Janowski, Miroslaw.

In: Journal of neurointerventional surgery, 01.01.2019.

Research output: Contribution to journalArticle

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