Abstract
Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.
| Original language | English (US) |
|---|---|
| Journal | Journal of neurointerventional surgery |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- brain
- intervention
- malignant
- MRI
- technique
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
Cite this
Republished : Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note. / Zawadzki, Michal; Walecki, Jerzy; Kostkiewicz, Boguslaw; Kostyra, Kacper; Pearl, Monica; Solaiyappan, Meiyappan; Walczak, Piotr; Janowski, Miroslaw.
In: Journal of neurointerventional surgery, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Republished
T2 - Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note
AU - Zawadzki, Michal
AU - Walecki, Jerzy
AU - Kostkiewicz, Boguslaw
AU - Kostyra, Kacper
AU - Pearl, Monica
AU - Solaiyappan, Meiyappan
AU - Walczak, Piotr
AU - Janowski, Miroslaw
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.
AB - Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.
KW - brain
KW - intervention
KW - malignant
KW - MRI
KW - technique
UR - http://www.scopus.com/inward/record.url?scp=85066158491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066158491&partnerID=8YFLogxK
U2 - 10.1136/neurintsurg-2018-014469.rep
DO - 10.1136/neurintsurg-2018-014469.rep
M3 - Article
C2 - 31123186
AN - SCOPUS:85066158491
JO - Journal of NeuroInterventional Surgery
JF - Journal of NeuroInterventional Surgery
SN - 1759-8478
ER -