Abstract
It has become evident that tumor-induced immuno-suppressive factors in the tumor microenvironment play a major role in suppressing normal functions of effector T cells. These factors serve as hurdles that limit the therapeutic potential of cancer immunotherapies. This review focuses on illustrating the molecular mechanisms of immunosuppression in the tumor microenvironment, including evasion of T-cell recognition, interference with T-cell trafficking, metabolism, and functions, induction of resistance to T-cell killing, and apoptosis of T cells. A better understanding of these mechanisms may help in the development of strategies to enhance the effectiveness of cancer immunotherapies.
Original language | English (US) |
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Pages (from-to) | 1-14 |
Number of pages | 14 |
Journal | OncoImmunology |
Volume | 4 |
Issue number | 7 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- Immunosuppression
- Immunosuppressive factors
- Immunotherapy
- T cells
- Tumor microenvironment
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology