Reprogramming somatic cells into pluripotent stem cells using miRNAs

Research output: Contribution to journalArticlepeer-review

Abstract

Reversal of terminally differentiated somatic cells to ground-state pluripotency has rejuvenated our hopes of generating patient-specific stem cells for therapeutic use in regenerative medicine and drug screening. Originally generated using defined exogenous protein-coding DNA, several methods have been described in reprogramming somatic cells into iPSC. Majority of published methods seek to improve or refine the techniques of reprogramming. This chapter describes reprogramming to pluripotency using miRNAs.

Original languageEnglish (US)
Pages (from-to)273-281
Number of pages9
JournalMethods in Molecular Biology
Volume1150
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Fibroblast
  • Induced pluripotent stem cells (iPSCs)
  • Lentivirus
  • MicroRNAs (miRNAs)
  • Reprogramming

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Reprogramming somatic cells into pluripotent stem cells using miRNAs'. Together they form a unique fingerprint.

Cite this