Reproductive risk factors and coronary heart disease in the women's health initiative observational study

Nisha I. Parikh, Rebecca P. Jeppson, Jeffrey S. Berger, Charles B. Eaton, Candyce H. Kroenke, Erin S. Leblanc, Cora E. Lewis, Eric B. Loucks, Donna Parker, Eileen Rillamas-Sun, Kelli K. Ryckman, Molly E. Waring, Robert S. Schenken, Karen C. Johnson, Anna Karin Edstedt-Bonamy, Matthew A. Allison, Barbara V. Howard

Research output: Contribution to journalArticle

Abstract

Background - Reproductive factors provide an early window into a woman's coronary heart disease (CHD) risk; however, their contribution to CHD risk stratification is uncertain. Methods and Results - In the Women's Health Initiative Observational Study, we constructed Cox proportional hazards models for CHD including age, pregnancy status, number of live births, age at menarche, menstrual irregularity, age at first birth, stillbirths, miscarriages, infertility ≥1 year, infertility cause, and breastfeeding. We next added each candidate reproductive factor to an established CHD risk factor model. A final model was then constructed with significant reproductive factors added to established CHD risk factors. Improvement in C statistic, net reclassification index (or net reclassification index with risk categories of

Original languageEnglish (US)
Pages (from-to)2149-2158
Number of pages10
JournalCirculation
Volume133
Issue number22
DOIs
StatePublished - May 31 2016
Externally publishedYes

Fingerprint

Women's Health
Observational Studies
Coronary Disease
Infertility
Menarche
Birth Order
Stillbirth
Live Birth
Spontaneous Abortion
Breast Feeding
Proportional Hazards Models
Pregnancy

Keywords

  • coronary disease
  • reproductive history
  • risk adjustment
  • spontaneous abortion
  • women

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Parikh, N. I., Jeppson, R. P., Berger, J. S., Eaton, C. B., Kroenke, C. H., Leblanc, E. S., ... Howard, B. V. (2016). Reproductive risk factors and coronary heart disease in the women's health initiative observational study. Circulation, 133(22), 2149-2158. https://doi.org/10.1161/CIRCULATIONAHA.115.017854

Reproductive risk factors and coronary heart disease in the women's health initiative observational study. / Parikh, Nisha I.; Jeppson, Rebecca P.; Berger, Jeffrey S.; Eaton, Charles B.; Kroenke, Candyce H.; Leblanc, Erin S.; Lewis, Cora E.; Loucks, Eric B.; Parker, Donna; Rillamas-Sun, Eileen; Ryckman, Kelli K.; Waring, Molly E.; Schenken, Robert S.; Johnson, Karen C.; Edstedt-Bonamy, Anna Karin; Allison, Matthew A.; Howard, Barbara V.

In: Circulation, Vol. 133, No. 22, 31.05.2016, p. 2149-2158.

Research output: Contribution to journalArticle

Parikh, NI, Jeppson, RP, Berger, JS, Eaton, CB, Kroenke, CH, Leblanc, ES, Lewis, CE, Loucks, EB, Parker, D, Rillamas-Sun, E, Ryckman, KK, Waring, ME, Schenken, RS, Johnson, KC, Edstedt-Bonamy, AK, Allison, MA & Howard, BV 2016, 'Reproductive risk factors and coronary heart disease in the women's health initiative observational study', Circulation, vol. 133, no. 22, pp. 2149-2158. https://doi.org/10.1161/CIRCULATIONAHA.115.017854
Parikh, Nisha I. ; Jeppson, Rebecca P. ; Berger, Jeffrey S. ; Eaton, Charles B. ; Kroenke, Candyce H. ; Leblanc, Erin S. ; Lewis, Cora E. ; Loucks, Eric B. ; Parker, Donna ; Rillamas-Sun, Eileen ; Ryckman, Kelli K. ; Waring, Molly E. ; Schenken, Robert S. ; Johnson, Karen C. ; Edstedt-Bonamy, Anna Karin ; Allison, Matthew A. ; Howard, Barbara V. / Reproductive risk factors and coronary heart disease in the women's health initiative observational study. In: Circulation. 2016 ; Vol. 133, No. 22. pp. 2149-2158.
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