Reproductive impact of MRI-guided focused ultrasound surgery for fibroids: A systematic review of the evidence

Natalie A. Clark, Sunni L. Mumford, James H. Segars

Research output: Contribution to journalReview articlepeer-review


Purpose of review: Magnetic-resonance-guided focused ultrasound surgery (MRgFUS) is a minimally invasive technique for the treatment of uterine fibroids. The purpose of this review is to highlight the impact of MRgFUS on fertility and reproductive outcomes. Recent findings: The role of MRgFUS in the treatment of fibroids has been evolving since its introduction in 2004. Several new devices and techniques including location-specific treatment, volumetric therapy, and vessel-targeted therapy have been introduced over the last few years. Several case series report uncomplicated pregnancy following MRgFUS; however, results of the ongoing studies will further elucidate the utility of MRgFUS in patients planning future fertility. A systematic review of the literature was completed and studies that reported quality of life at baseline and after 6 months were included in a meta-analysis. Summary: MRgFUS represents a minimally invasive treatment for uterine fibroids that is able to improve the quality of life and fibroid size with durability. It is possible that MRgFUS could be the treatment of choice for patients desiring future fertility; however, further investigation is needed.

Original languageEnglish (US)
Pages (from-to)151-161
Number of pages11
JournalCurrent Opinion in Obstetrics and Gynecology
Issue number3
StatePublished - Jun 2014
Externally publishedYes


  • HIFU
  • MRgFUS
  • fertility
  • fibroids
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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