Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk

Sue Kyung Park, Daehee Kang, Dong Young Noh, Kyoung Mu Lee, Sook Un Kim, Ji Yeob Choi, In Mi Choi, Se Hyun Ahn, Kuk Jin Choe, Ari Hirvonen, Paul T. Strickland, Keun Young Yoo

Research output: Contribution to journalArticle

Abstract

We conducted a hospital-based case-control study to evaluate the interactive effect of reproductive factors and glutathione S-transferase (GST) M1 and T1 genetic polymorphisms in individual susceptibility to breast cancer. The study population consisted of 189 incident breast cancer cases and 189 age-matched controls with no known malignant diseases. GSTM1/T1 genotypes were determined by a multiplex polymerase chain reaction (PCR) method, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression model. The parity factors were grouped as (1) high-risk status defined as nullipara or para with experience of first full-term pregnancy (FFTP) at or over 30 years, and (2) low-risk status defined as para with experience of FFTP under 30 years. A significant multiplicative interaction was observed between GSTM1 and GSTT1 null genotypes and high-risk status of parity factor in all women and in premenopausal women (P ≤ 0.01), but not in postmenopausal women (P > 0.05). The interaction between the combined genotypes of GSTM1 and GSTT1 and status of parity factor was also significant in all women and in premenopausal women (P < 0.01). Our findings suggest that genetic polymorphisms GSTM1/T1 could modify estrogen-related breast cancer risk.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalBreast Cancer Research and Treatment
Volume78
Issue number1
DOIs
StatePublished - Mar 1 2003

Keywords

  • Breast cancer
  • GSTM1
  • GSTT1
  • Genetic polymorphisms
  • Interaction
  • Reproductive factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk'. Together they form a unique fingerprint.

  • Cite this

    Park, S. K., Kang, D., Noh, D. Y., Lee, K. M., Kim, S. U., Choi, J. Y., Choi, I. M., Ahn, S. H., Choe, K. J., Hirvonen, A., Strickland, P. T., & Yoo, K. Y. (2003). Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk. Breast Cancer Research and Treatment, 78(1), 89-96. https://doi.org/10.1023/A:1022113713226