Reproducibility of Peak Oxygen Uptake and Other Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing)

Daniel R. Bensimhon, Eric S. Leifer, Stephen J. Ellis, Jerome L. Fleg, Steven J. Keteyian, Ileana L. Piña, Dalane W. Kitzman, Robert S. McKelvie, William E. Kraus, Daniel E. Forman, Andrew J. Kao, David J. Whellan, Christopher M. O'Connor, Stuart D. Russell

Research output: Contribution to journalArticle

Abstract

Peak oxygen uptake (pVo2) is an important parameter in assessing the functional capacity and prognosis of patients with heart failure. In heart failure trials, change in pVo2 was often used to assess the effectiveness of an intervention. However, the within-subject variability of pVo2 on serial testing may limit its usefulness. This study was designed to evaluate the within-subject variability of pVo2 over 2 baseline cardiopulmonary exercise tests. As a substudy of the HF-ACTION trial, 398 subjects (73% men, 27% women; mean age 59 years) with heart failure and left ventricular ejection fraction ≤35% underwent 2 baseline cardiopulmonary exercise tests within 14 days. Mean pVo2 was unchanged from test 1 to test 2 (15.16 ± 4.97 vs 15.18 ± 4.97 ml/kg/min; p = 0.78). However, mean within-subject absolute change was 1.3 ml/kg/min (10th, 90th percentiles 0.1, 3.0), with 46% of subjects increasing and 48% decreasing on the second test. Other parameters, including the ventilation-to-carbon-dioxide production slope and Vo2 at ventilatory threshold, also showed significant within-subject variation with minimal mean differences between tests. In conclusion, pVo2 showed substantial within-subject variability in patients with heart failure and should be taken into account in clinical applications. However, on repeated baseline cardiopulmonary exercise tests, there appears to be no familiarization effect for Vo2 in patients with HF. Therefore, in multicenter trials, there is no need to perform >1 baseline cardiopulmonary exercise test.

Original languageEnglish (US)
Pages (from-to)712-717
Number of pages6
JournalThe American Journal of Cardiology
Volume102
Issue number6
DOIs
StatePublished - Sep 15 2008

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Exercise Test
Heart Failure
Exercise
Oxygen
Carbon Dioxide
Stroke Volume
Multicenter Studies
Ventilation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Reproducibility of Peak Oxygen Uptake and Other Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing). / Bensimhon, Daniel R.; Leifer, Eric S.; Ellis, Stephen J.; Fleg, Jerome L.; Keteyian, Steven J.; Piña, Ileana L.; Kitzman, Dalane W.; McKelvie, Robert S.; Kraus, William E.; Forman, Daniel E.; Kao, Andrew J.; Whellan, David J.; O'Connor, Christopher M.; Russell, Stuart D.

In: The American Journal of Cardiology, Vol. 102, No. 6, 15.09.2008, p. 712-717.

Research output: Contribution to journalArticle

Bensimhon, DR, Leifer, ES, Ellis, SJ, Fleg, JL, Keteyian, SJ, Piña, IL, Kitzman, DW, McKelvie, RS, Kraus, WE, Forman, DE, Kao, AJ, Whellan, DJ, O'Connor, CM & Russell, SD 2008, 'Reproducibility of Peak Oxygen Uptake and Other Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing)', The American Journal of Cardiology, vol. 102, no. 6, pp. 712-717. https://doi.org/10.1016/j.amjcard.2008.04.047
Bensimhon, Daniel R. ; Leifer, Eric S. ; Ellis, Stephen J. ; Fleg, Jerome L. ; Keteyian, Steven J. ; Piña, Ileana L. ; Kitzman, Dalane W. ; McKelvie, Robert S. ; Kraus, William E. ; Forman, Daniel E. ; Kao, Andrew J. ; Whellan, David J. ; O'Connor, Christopher M. ; Russell, Stuart D. / Reproducibility of Peak Oxygen Uptake and Other Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing). In: The American Journal of Cardiology. 2008 ; Vol. 102, No. 6. pp. 712-717.
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abstract = "Peak oxygen uptake (pVo2) is an important parameter in assessing the functional capacity and prognosis of patients with heart failure. In heart failure trials, change in pVo2 was often used to assess the effectiveness of an intervention. However, the within-subject variability of pVo2 on serial testing may limit its usefulness. This study was designed to evaluate the within-subject variability of pVo2 over 2 baseline cardiopulmonary exercise tests. As a substudy of the HF-ACTION trial, 398 subjects (73{\%} men, 27{\%} women; mean age 59 years) with heart failure and left ventricular ejection fraction ≤35{\%} underwent 2 baseline cardiopulmonary exercise tests within 14 days. Mean pVo2 was unchanged from test 1 to test 2 (15.16 ± 4.97 vs 15.18 ± 4.97 ml/kg/min; p = 0.78). However, mean within-subject absolute change was 1.3 ml/kg/min (10th, 90th percentiles 0.1, 3.0), with 46{\%} of subjects increasing and 48{\%} decreasing on the second test. Other parameters, including the ventilation-to-carbon-dioxide production slope and Vo2 at ventilatory threshold, also showed significant within-subject variation with minimal mean differences between tests. In conclusion, pVo2 showed substantial within-subject variability in patients with heart failure and should be taken into account in clinical applications. However, on repeated baseline cardiopulmonary exercise tests, there appears to be no familiarization effect for Vo2 in patients with HF. Therefore, in multicenter trials, there is no need to perform >1 baseline cardiopulmonary exercise test.",
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AU - Forman, Daniel E.

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