Reproducibility of human 3D fMRI brain maps acquired during a motor task

Nick F. Ramsey, Kathleen Tallent, Peter Van Gelderen, Joseph A. Frank, Chrit T.W. Moonen, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

This study is an investigation into the reproducibility of brain activation in the sensorimotor cortex obtained with 3D 'PRESTO' fMRI on eleven normal subjects. During one session, two series of functional scans were acquired while the subjects performed a finger opposition task (2 Hz). Nine subjects were tested once more on a different day. Each individual motor trial was analyzed separately, with a conservative z(t)-based method. Using these results, the agreement between repeated series was examined in a number of ways, comparing the two series within one session, and the two series across sessions. In 28 of the 31 series (90%) significant signal change was found in the contralateral primary sensorimotor cortex (PSM). Overall, 0.20% of all voxels (total about 11,000) in the scanned volume reached significance, and approximately 60% of the significant positive signal changes were located in the PSM (P < 5 x 10-7 for a chance occurrence). Comparisons within and across sessions yielded similar results: there was a 20,30% overlap of the clusters of activated voxels in the PSM (chance overlap within the PSM: P <: 0.01). The mean distance between z(t)-weighted centers of mass was 4.0-.4.4 mm (chance distance within the PSM: P = 0.033 and 0.058, respectively). No significant difference was found between series in the magnitude of significant signal change. Whereas the number of activated voxels in the PSM was not consistently correlated between series, the ratio of this number over the total number of activated voxels in the scanned volume was significantly correlated (rho = 0.75-0.79, P < 0.05). These results indicate that activation in sensorimotor cortex associated with oppositional finger movement is reliably mapped with 3D PRESTO fMRI.

Original languageEnglish (US)
Pages (from-to)113-121
Number of pages9
JournalHuman Brain Mapping
Volume4
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Magnetic Resonance Imaging
Brain
Fingers
Sensorimotor Cortex

Keywords

  • activation
  • cognitive neuroscience
  • magnetic resonance imaging
  • neuroimaging
  • topography

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Reproducibility of human 3D fMRI brain maps acquired during a motor task. / Ramsey, Nick F.; Tallent, Kathleen; Van Gelderen, Peter; Frank, Joseph A.; Moonen, Chrit T.W.; Weinberger, Daniel.

In: Human Brain Mapping, Vol. 4, No. 2, 1996, p. 113-121.

Research output: Contribution to journalArticle

Ramsey, Nick F. ; Tallent, Kathleen ; Van Gelderen, Peter ; Frank, Joseph A. ; Moonen, Chrit T.W. ; Weinberger, Daniel. / Reproducibility of human 3D fMRI brain maps acquired during a motor task. In: Human Brain Mapping. 1996 ; Vol. 4, No. 2. pp. 113-121.
@article{be7a9c6936314b728fb582944f36c9d3,
title = "Reproducibility of human 3D fMRI brain maps acquired during a motor task",
abstract = "This study is an investigation into the reproducibility of brain activation in the sensorimotor cortex obtained with 3D 'PRESTO' fMRI on eleven normal subjects. During one session, two series of functional scans were acquired while the subjects performed a finger opposition task (2 Hz). Nine subjects were tested once more on a different day. Each individual motor trial was analyzed separately, with a conservative z(t)-based method. Using these results, the agreement between repeated series was examined in a number of ways, comparing the two series within one session, and the two series across sessions. In 28 of the 31 series (90{\%}) significant signal change was found in the contralateral primary sensorimotor cortex (PSM). Overall, 0.20{\%} of all voxels (total about 11,000) in the scanned volume reached significance, and approximately 60{\%} of the significant positive signal changes were located in the PSM (P < 5 x 10-7 for a chance occurrence). Comparisons within and across sessions yielded similar results: there was a 20,30{\%} overlap of the clusters of activated voxels in the PSM (chance overlap within the PSM: P <: 0.01). The mean distance between z(t)-weighted centers of mass was 4.0-.4.4 mm (chance distance within the PSM: P = 0.033 and 0.058, respectively). No significant difference was found between series in the magnitude of significant signal change. Whereas the number of activated voxels in the PSM was not consistently correlated between series, the ratio of this number over the total number of activated voxels in the scanned volume was significantly correlated (rho = 0.75-0.79, P < 0.05). These results indicate that activation in sensorimotor cortex associated with oppositional finger movement is reliably mapped with 3D PRESTO fMRI.",
keywords = "activation, cognitive neuroscience, magnetic resonance imaging, neuroimaging, topography",
author = "Ramsey, {Nick F.} and Kathleen Tallent and {Van Gelderen}, Peter and Frank, {Joseph A.} and Moonen, {Chrit T.W.} and Daniel Weinberger",
year = "1996",
doi = "10.1002/(SICI)1097-0193(1996)4:2<113::AID-HBM3>3.0.CO;2-6",
language = "English (US)",
volume = "4",
pages = "113--121",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Reproducibility of human 3D fMRI brain maps acquired during a motor task

AU - Ramsey, Nick F.

AU - Tallent, Kathleen

AU - Van Gelderen, Peter

AU - Frank, Joseph A.

AU - Moonen, Chrit T.W.

AU - Weinberger, Daniel

PY - 1996

Y1 - 1996

N2 - This study is an investigation into the reproducibility of brain activation in the sensorimotor cortex obtained with 3D 'PRESTO' fMRI on eleven normal subjects. During one session, two series of functional scans were acquired while the subjects performed a finger opposition task (2 Hz). Nine subjects were tested once more on a different day. Each individual motor trial was analyzed separately, with a conservative z(t)-based method. Using these results, the agreement between repeated series was examined in a number of ways, comparing the two series within one session, and the two series across sessions. In 28 of the 31 series (90%) significant signal change was found in the contralateral primary sensorimotor cortex (PSM). Overall, 0.20% of all voxels (total about 11,000) in the scanned volume reached significance, and approximately 60% of the significant positive signal changes were located in the PSM (P < 5 x 10-7 for a chance occurrence). Comparisons within and across sessions yielded similar results: there was a 20,30% overlap of the clusters of activated voxels in the PSM (chance overlap within the PSM: P <: 0.01). The mean distance between z(t)-weighted centers of mass was 4.0-.4.4 mm (chance distance within the PSM: P = 0.033 and 0.058, respectively). No significant difference was found between series in the magnitude of significant signal change. Whereas the number of activated voxels in the PSM was not consistently correlated between series, the ratio of this number over the total number of activated voxels in the scanned volume was significantly correlated (rho = 0.75-0.79, P < 0.05). These results indicate that activation in sensorimotor cortex associated with oppositional finger movement is reliably mapped with 3D PRESTO fMRI.

AB - This study is an investigation into the reproducibility of brain activation in the sensorimotor cortex obtained with 3D 'PRESTO' fMRI on eleven normal subjects. During one session, two series of functional scans were acquired while the subjects performed a finger opposition task (2 Hz). Nine subjects were tested once more on a different day. Each individual motor trial was analyzed separately, with a conservative z(t)-based method. Using these results, the agreement between repeated series was examined in a number of ways, comparing the two series within one session, and the two series across sessions. In 28 of the 31 series (90%) significant signal change was found in the contralateral primary sensorimotor cortex (PSM). Overall, 0.20% of all voxels (total about 11,000) in the scanned volume reached significance, and approximately 60% of the significant positive signal changes were located in the PSM (P < 5 x 10-7 for a chance occurrence). Comparisons within and across sessions yielded similar results: there was a 20,30% overlap of the clusters of activated voxels in the PSM (chance overlap within the PSM: P <: 0.01). The mean distance between z(t)-weighted centers of mass was 4.0-.4.4 mm (chance distance within the PSM: P = 0.033 and 0.058, respectively). No significant difference was found between series in the magnitude of significant signal change. Whereas the number of activated voxels in the PSM was not consistently correlated between series, the ratio of this number over the total number of activated voxels in the scanned volume was significantly correlated (rho = 0.75-0.79, P < 0.05). These results indicate that activation in sensorimotor cortex associated with oppositional finger movement is reliably mapped with 3D PRESTO fMRI.

KW - activation

KW - cognitive neuroscience

KW - magnetic resonance imaging

KW - neuroimaging

KW - topography

UR - http://www.scopus.com/inward/record.url?scp=0029764864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029764864&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0193(1996)4:2<113::AID-HBM3>3.0.CO;2-6

DO - 10.1002/(SICI)1097-0193(1996)4:2<113::AID-HBM3>3.0.CO;2-6

M3 - Article

C2 - 20408191

AN - SCOPUS:0029764864

VL - 4

SP - 113

EP - 121

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 2

ER -