Reproducibility of gastric tone, compliance and gastric accommodation assessed with barostat in conscious dogs

J. H. Xing, Jiande D.Z. Chen

Research output: Contribution to journalArticle

Abstract

The reproducibility of baiostat measurements was unclear. In this study, the intraday and interday reproducibility of barostat measurements of gastric tone, compliance and gastric accommodation were assessed in a canine model. A series of experiments were performed using a barostat system in 11 surgically prepared healthy dogs: (i) interday gastric tone and compliance: three sessions on three separate days; (ii) intraday gastric tone and compliance: two sessions on the same day separated by a 30-min interval; (iii) interday gastric accommodation: two sessions on two separate days, with each including a 30-min baseline and a 60-min postprandial period. The results were (i) interday gastric tone (81.2 ± 7.5 mL vs 89.2 ± 8.1 mL vs 86.2 ± 13.6 mL, n = 11) and compliance (n = 8) were comparable; (ii) intraday gastric tone (87.9 ± 17.2 mL vs 77.0 ± 14.8 mL, n = 8) and compliance (n = 8) was also similar, but with considerable individual variance; (iii) interday gastric accommodation was 320.8 ± 45.1 mL vs 287.9 ± 31.2 mL, no significant difference (n = 8). Inter- and intraday gastric tone and compliance and interday gastric accommodation were relatively reproducible in most animals when tested under well-controlled conditions. However, considerable variations may occur in fasting gastric tone and compliance measurements in certain individuals and cautions should be given when interpreting related results.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalNeurogastroenterology and Motility
Volume17
Issue number1
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Keywords

  • Barostat
  • Gastric accommodation
  • Gastric compliance
  • Gastric tone

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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