TY - JOUR
T1 - Reproducibility of CT measurements of aortic valve calcification, mitral annulus calcification, and aortic wall calcification in the multi-ethnic study of atherosclerosis
AU - Budoff, Matthew J.
AU - Takasu, Junichiro
AU - Katz, Ronit
AU - Mao, Songshou
AU - Shavelle, David M.
AU - O'Brien, Kevin D.
AU - Blumenthal, Roger S.
AU - Carr, J. Jeffrey
AU - Kronmal, Richard
N1 - Funding Information:
This research was supported by R01-HL-63963-01A1 and contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute.
PY - 2006/2
Y1 - 2006/2
N2 - Rationale and Objectives. Extracoronary calcifications may have clinical significance. The error in extracoronary calcification measurements is still unknown. Accurate quantification of calcifications of the aortic valve (AVC), mitral annulus (MAC), and aortic wall (AWC) may be possible by using cardiac computed tomography (CT). We sought to establish the interscan, interobserver, and intraobserver reproducibility of these measures in all cardiac CT scans in the Multi-Ethnic Study of Atherosclerosis. Materials and Methods. We measured extracoronary calcifications in 100 randomly selected participants to assess interobserver, interscan, and intraobserver variability. Two scans were available for analysis in 99 of these participants, and we quantified thoracic aorta and valvular calcifications. Results. Mean interscan variability of AVC was 9.7% ± 11.4% and 8% ± 10.3% for Agatston and volume scores, with variability of the median at 6.4% and 5.5%, respectively (P > .05). MAC inter-reader variability was 8.2% and 8.9%, with interscan variability of 28% and 33% and intrareader variability of 4% and 4.1%, respectively. For AWC, inter-reader variability was 3%-7.1%, interscan variability was 17%-18%, and intrareader variability was 0.4%-1.4%. Conclusion. AVC, MAC, and AWC measurements are sufficiently reproducible to allow serial investigations over a time suitable for clinical studies.
AB - Rationale and Objectives. Extracoronary calcifications may have clinical significance. The error in extracoronary calcification measurements is still unknown. Accurate quantification of calcifications of the aortic valve (AVC), mitral annulus (MAC), and aortic wall (AWC) may be possible by using cardiac computed tomography (CT). We sought to establish the interscan, interobserver, and intraobserver reproducibility of these measures in all cardiac CT scans in the Multi-Ethnic Study of Atherosclerosis. Materials and Methods. We measured extracoronary calcifications in 100 randomly selected participants to assess interobserver, interscan, and intraobserver variability. Two scans were available for analysis in 99 of these participants, and we quantified thoracic aorta and valvular calcifications. Results. Mean interscan variability of AVC was 9.7% ± 11.4% and 8% ± 10.3% for Agatston and volume scores, with variability of the median at 6.4% and 5.5%, respectively (P > .05). MAC inter-reader variability was 8.2% and 8.9%, with interscan variability of 28% and 33% and intrareader variability of 4% and 4.1%, respectively. For AWC, inter-reader variability was 3%-7.1%, interscan variability was 17%-18%, and intrareader variability was 0.4%-1.4%. Conclusion. AVC, MAC, and AWC measurements are sufficiently reproducible to allow serial investigations over a time suitable for clinical studies.
KW - Aortic calcification
KW - Aortic valve
KW - Cardiac CT
KW - Mitral annular calcification
KW - Reproducibility
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U2 - 10.1016/j.acra.2005.09.090
DO - 10.1016/j.acra.2005.09.090
M3 - Article
C2 - 16428051
AN - SCOPUS:31044444136
SN - 1076-6332
VL - 13
SP - 166
EP - 172
JO - Academic radiology
JF - Academic radiology
IS - 2
ER -