Reproducibility of brain MRS in older healthy adults at 7T

S. Andrea Wijtenburg, Laura M. Rowland, Georg Oeltzschner, Peter B. Barker, Clifford I. Workman, Gwenn S. Smith

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


To date, the majority of MRS reproducibility studies have been conducted in healthy younger adults, with only a few conducted in older adults at 3 T. With the growing interest in applying MRS methods to study the longitudinal course and effects of treatments in neurodegenerative disease, it is important to establish reproducibility in age-matched controls, especially in older individuals. In this study, spectroscopic data were acquired using a stimulated echo acquisition mode (STEAM) localization technique in two regions (anterior and posterior cingulate cortices—ACC, PCC, respectively) in 10 healthy, cognitively normal older adults (64 ± 8.1 years). Reproducibility was assessed via mean coefficients of variation (CVs) and relative differences (RDs) calculated across two visits performed 2–3 months apart. Metabolites with high signal-to-noise ratio (SNR) such as NAA, tCho, and Glu had mean CVs of 10% or less and mean RDs of 15% or less across both regions. Metabolites with lower SNR such as GABA and Gln had slightly higher mean CVs of 22% or less and mean RDs of 27% or less across both regions. These results demonstrate the feasibility of acquiring MRS data at 7 T in older subjects, and establish that the spectroscopic data are reproducible in both the ACC and PCC in older, healthy subjects to the same extent as in previous studies in young subjects.

Original languageEnglish (US)
Article numbere4040
JournalNMR in biomedicine
Issue number2
StatePublished - Feb 2019


  • 7 T
  • MRS
  • anterior cingulate cortex
  • older adults
  • posterior cingulate cortex
  • reproducibility

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


Dive into the research topics of 'Reproducibility of brain MRS in older healthy adults at 7T'. Together they form a unique fingerprint.

Cite this