Reprint: Inflammatory findings on species extrapolations: Humans are definitely no 70-kg mice1

Marcel Leist, Thomas Hartung

Research output: Contribution to journalReview article

Abstract

Modern toxicology has embraced in vitro methods, and major hopes are based on the omics technologies and systems biology approaches they bring along (Hartung and McBride, 2011; Hartung et al., 2012). A culture of stringent validation has been developed for such approaches (Leist et al., 2010, 2012a,b), while the quality and usefulness of animal experiments have been little scrutinized. A new study (Seok et al., 2013) now shows the low predictivity of animal responses in the field of inflammation. These findings corroborate earlier findings from comparisons in the fields of neurodegeneration, stroke and sepsis. The low predictivity of animal experiments in research areas allowing direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key technology to predict human safety.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalALTEX
Volume30
Issue number2
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Pharmacology
  • Medical Laboratory Technology

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