Representation of internal models of action in the autistic brain

Courtney C. Haswell, Jun Izawa, Lauren R Dowell, Stewart H Mostofsky, Reza Shadmehr

Research output: Contribution to journalArticlepeer-review

Abstract

Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.

Original languageEnglish (US)
Pages (from-to)970-972
Number of pages3
JournalNature neuroscience
Volume12
Issue number8
DOIs
StatePublished - Aug 2009

ASJC Scopus subject areas

  • Neuroscience(all)

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