Reporting trends and prognostic significance of lymphovascular invasion in muscle-invasive urothelial carcinoma: A population-based study

David M. Berman, Atsunari Kawashima, Yingwei Peng, William J. Mackillop, D. Robert Siemens, Christopher M. Booth

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate reporting patterns and outcomes associated with lymphovascular invasion in a general population setting. Methods: We identified all cystectomy patients with muscle-invasive urothelial cancer in Ontario, Canada, 1994-2008. Surgical pathology reports were analyzed for pathological variables including lymphovascular invasion. Lymphovascular invasion reporting patterns were described over time. A Cox proportional hazards model was used to evaluate the association of lymphovascular invasion with survival. Results: Of the 2802 cases identified, lymphovascular invasion status was reported in 75%. Lymphovascular invasion reporting significantly improved over the study period and was correlated with poor prognostic pathological features (T stage and N stage). Comprehensive cancer center status was not consistently associated with lymphovascular invasion reporting. Patients with lymphovascular invasion had substantially lower survival than patients who were lymphovascular invasion-negative or whose lymphovascular invasion status was unstated (P

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalInternational Journal of Urology
Volume22
Issue number2
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

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Carcinoma
Muscles
Population
Surgical Pathology
Survival
Cystectomy
Ontario
Proportional Hazards Models
Canada
Neoplasms

Keywords

  • Adjuvant chemotherapy
  • Cystectomy
  • Diagnostic bias
  • Lymphovascular invasion
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Reporting trends and prognostic significance of lymphovascular invasion in muscle-invasive urothelial carcinoma : A population-based study. / Berman, David M.; Kawashima, Atsunari; Peng, Yingwei; Mackillop, William J.; Siemens, D. Robert; Booth, Christopher M.

In: International Journal of Urology, Vol. 22, No. 2, 01.02.2015, p. 163-170.

Research output: Contribution to journalArticle

Berman, David M. ; Kawashima, Atsunari ; Peng, Yingwei ; Mackillop, William J. ; Siemens, D. Robert ; Booth, Christopher M. / Reporting trends and prognostic significance of lymphovascular invasion in muscle-invasive urothelial carcinoma : A population-based study. In: International Journal of Urology. 2015 ; Vol. 22, No. 2. pp. 163-170.
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