Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems

Sohum Mehta, Jin Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Real-time visualization of a wide range of biochemical processes in living systems is being made possible through the development and application of genetically encoded fluorescent reporters. These versatile biosensors have proven themselves tailor-made to the study of signal transduction, and in this review, we discuss some of the unique insights that they continue to provide regarding the spatial organization and dynamic regulation of intracellular signaling networks. In addition, we explore the more recent push to expand the scope of biological phenomena that can be monitored using these reporters, while also considering the potential to integrate this highly adaptable technology with a number of emerging techniques that may significantly broaden our view of how networks of biochemical processes shape larger biological phenomena.

Original languageEnglish (US)
Pages (from-to)375-401
Number of pages27
JournalAnnual Review of Biochemistry
Volume80
DOIs
StatePublished - Jul 7 2011

Keywords

  • Spatiotemporal dynamics

ASJC Scopus subject areas

  • Biochemistry

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