TY - JOUR
T1 - Reporting and staging of testicular germ cell tumors
T2 - The international society of urological pathology (ISUP) testicular cancer consultation conference recommendations
AU - Members of the International Society of Urological Pathology Testicular Tumor Panel
AU - Verrill, Clare
AU - Yilmaz, Asli
AU - Srigley, John R.
AU - Amin, Mahul B.
AU - Compérat, Eva
AU - Egevad, Lars
AU - Ulbright, Thomas M.
AU - Tickoo, Satish K.
AU - Berney, Daniel M.
AU - Epstein, Jonathan I.
AU - Delahunt, Brett
AU - Magi-Galluzzi, Cristina
AU - Algaba, Ferran
AU - Oliva, Esther
AU - Montironi, Rodolfo
AU - Young, Robert H.
AU - Idrees, Muhammad T.
AU - Williamson, Sean R.
AU - Zhou, Ming
AU - Humphrey, Peter A.
AU - Lopez-Beltran, Antonio
AU - Perry-Keene, Joanna
N1 - Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - The International Society of Urological Pathology held a conference devoted to issues in testicular and penile pathology in Boston in March 2015, which included a presentation and discussion led by the testis microscopic features working group. This conference focused on controversies related to staging and reporting of testicular tumors and was preceded by an online survey of the International Society of Urological Pathology members. The survey results were used to initiate discussions, but decisions were made by expert consensus rather than voting. A number of recommendations emerged from the conference, including that lymphovascular invasion (LVI) should always be reported and no distinction need be made between lymphatic or blood invasion. If LVI is equivocal, then it should be regarded as negative to avoid triggering unnecessary therapy. LVI in the spermatic cord is considered as category pT2, not pT3, unless future studies provide contrary evidence. At the time of gross dissection, a block should be taken just superior to the epididymis to define the base of the spermatic cord, and direct invasion of tumor in this block indicates a category of pT3. Pagetoid involvement of the rete testis epithelium must be distinguished from rete testis stromal invasion, with only the latter being prognostically useful. Percentages of different tumor elements in mixed germ cell tumors should be reported. Although consensus was reached on many issues, there are still areas of practice that need further evidence on which to base firm recommendations.
AB - The International Society of Urological Pathology held a conference devoted to issues in testicular and penile pathology in Boston in March 2015, which included a presentation and discussion led by the testis microscopic features working group. This conference focused on controversies related to staging and reporting of testicular tumors and was preceded by an online survey of the International Society of Urological Pathology members. The survey results were used to initiate discussions, but decisions were made by expert consensus rather than voting. A number of recommendations emerged from the conference, including that lymphovascular invasion (LVI) should always be reported and no distinction need be made between lymphatic or blood invasion. If LVI is equivocal, then it should be regarded as negative to avoid triggering unnecessary therapy. LVI in the spermatic cord is considered as category pT2, not pT3, unless future studies provide contrary evidence. At the time of gross dissection, a block should be taken just superior to the epididymis to define the base of the spermatic cord, and direct invasion of tumor in this block indicates a category of pT3. Pagetoid involvement of the rete testis epithelium must be distinguished from rete testis stromal invasion, with only the latter being prognostically useful. Percentages of different tumor elements in mixed germ cell tumors should be reported. Although consensus was reached on many issues, there are still areas of practice that need further evidence on which to base firm recommendations.
KW - ISUP conference recommendations
KW - Reporting and staging
KW - Testicular germ cell tumors
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U2 - 10.1097/PAS.0000000000000844
DO - 10.1097/PAS.0000000000000844
M3 - Article
C2 - 28368923
AN - SCOPUS:85016946858
SN - 0147-5185
VL - 41
SP - e22-e32
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 6
ER -