Report of the committee on the genetic constitution of chromosomes 10, 11 and 12

Since HGM8, ten new genes have been added to the map of chromosome 10 which now includes 34 genes, 7D segments and 2 fragile sites. In addition, one disease gene for multiple endocrine neoplasia, type 2 (MEN2A), (Ponder et al. HGM9 Simpson et al. HGM9) has been mapped to chromosome 10. The Utah group (Nakamura et al. HGM9) has mapped an additional 11 probes to 10; the Collaborative Research group (Smith et al. HGM9) has mapped 6 probes to 10. Thus the total number of anonymous probes now on 10 and placed in linkage groups is 28. At this conference, five new genes have been assigned to human chromosome 11: tryptophan hydroxylase (TRPH), lactate dehydrogenase C (LDHC), the gene of the human signal recognition particle receptor (SRPR), the gene for stromelysin (STMY), and a new putative oncogene c-sea (SEA). Since HGM8, 10 genes have been added to the map of chromosome 12 which previously contained 52 genes and 2 fragile sites. The present map of 12 contains 61 genes, 12 D segments and 2 fragile sites for a total of 76 entries. One gene, TP12, was deleted from the map.