TY - JOUR
T1 - Report of an ISRTP Workshop
T2 - Progress and barriers to incorporating alternative toxicological methods in the U.S.
AU - Becker, Richard A.
AU - Borgert, Christopher J.
AU - Webb, Simon
AU - Ansell, Jay
AU - Amundson, Sara
AU - Portier, Christopher J.
AU - Goldberg, Alan
AU - Bruner, Leon H.
AU - Rowan, Andrew
AU - Curren, Rodger D.
AU - Stott, William T.
N1 - Funding Information:
This workshop was endorsed by the Society of Toxicology and funding was provided by The Proctor & Gamble Company, the National Institute of Environmental Health Sciences/National Toxicology Program, the American Chemistry Council, the Cosmetic, Toiletry, and Fragrance Association, the Dow Chemical Company, the United States Army Edgewood Chemical Biological Center, Yves Rocher North America, Inc., the Humane Society of the United States, and the Doris Day Animal League.
PY - 2006/10
Y1 - 2006/10
N2 - The workshop objectives were to explore progress in implementing new, revised and alternative toxicological test methods across regulatory evaluation frameworks and decision-making programs in the United States, to identify barriers and to develop recommendations to further promote adoption of approaches that reduce, refine, or replace the use of animal methods. The workshop included sessions on: (1) current research, development, and validation of alternative methods within the U.S. federal government; (2) emerging alternative methodologies with potential applications to a broad spectrum of toxicity evaluation strategies; (3) tiered evaluation ("intelligent testing") strategies; and (4) identification of, and recommendations to address, critical barriers that affect adoption and use of new, revised alternative toxicological test methods by U.S. regulatory agencies. Through facilitated discussion, a list of barriers and recommendations were developed and grouped into categories of economic/financial, scientific/technical, and regulatory/policy. Overall, participants from all sectors collectively supported catalyzing actions to promote more meaningful and rapid progress for research to develop alternative methods focused for use in regulatory programs, accelerated lab investigations to validate such alternative methods and adoption of regulatory frameworks which embrace and incorporate these validated alternatives.
AB - The workshop objectives were to explore progress in implementing new, revised and alternative toxicological test methods across regulatory evaluation frameworks and decision-making programs in the United States, to identify barriers and to develop recommendations to further promote adoption of approaches that reduce, refine, or replace the use of animal methods. The workshop included sessions on: (1) current research, development, and validation of alternative methods within the U.S. federal government; (2) emerging alternative methodologies with potential applications to a broad spectrum of toxicity evaluation strategies; (3) tiered evaluation ("intelligent testing") strategies; and (4) identification of, and recommendations to address, critical barriers that affect adoption and use of new, revised alternative toxicological test methods by U.S. regulatory agencies. Through facilitated discussion, a list of barriers and recommendations were developed and grouped into categories of economic/financial, scientific/technical, and regulatory/policy. Overall, participants from all sectors collectively supported catalyzing actions to promote more meaningful and rapid progress for research to develop alternative methods focused for use in regulatory programs, accelerated lab investigations to validate such alternative methods and adoption of regulatory frameworks which embrace and incorporate these validated alternatives.
KW - Alternative testing methods
KW - Animal testing
KW - Regulatory toxicology
UR - http://www.scopus.com/inward/record.url?scp=33747881023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747881023&partnerID=8YFLogxK
U2 - 10.1016/j.yrtph.2006.06.001
DO - 10.1016/j.yrtph.2006.06.001
M3 - Article
C2 - 16876299
AN - SCOPUS:33747881023
SN - 0273-2300
VL - 46
SP - 18
EP - 22
JO - Regulatory Toxicology and Pharmacology
JF - Regulatory Toxicology and Pharmacology
IS - 1
ER -