Repopulation of liver endothelium by bone-marrow-derived cells

Zu Hua Gao, Vivian C. McAlister, G. Melville Williams

Research output: Contribution to journalArticle

Abstract

The mechanism underlying the immunological advantage of hepatic allografts relative to other organs is incompletely understood. We used molecular probes for the repetitive units on the Y chromosome, to identify an increasing number of male liver venous endothelial cells in needle biopsy samples of men who received female donor liver grafts. We have also shown repopulation of liver endothelium by bone marrow derived cells in a male to female mouse bone marrow transplant model. We conclude that the liver has unique venous endothelium characterised by turnover and replacement by bone marrow derived cells.

Original languageEnglish (US)
Pages (from-to)932-933
Number of pages2
JournalLancet
Volume357
Issue number9260
DOIs
StatePublished - Mar 24 2001

ASJC Scopus subject areas

  • Medicine(all)

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    Gao, Z. H., McAlister, V. C., & Williams, G. M. (2001). Repopulation of liver endothelium by bone-marrow-derived cells. Lancet, 357(9260), 932-933. https://doi.org/10.1016/S0140-6736(00)04217-3