Replication of five prostate cancer loci identified in an Asian population - Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)

Sara Lindström, Fredrick R. Schumacher, Daniele Campa, Demetrius Albanes, Gerald Andriole, Sonja I. Berndt, H. Bas Bueno-de-Mesquita, Stephen J. Chanock, W. Ryan Diver, J. Michael Ganziano, Susan M. Gapstur, Edward Giovannucci, Christopher A. Haiman, Brian Henderson, David J. Hunter, Mattias Johansson, Laurence N. Kolonel, Loic Le Marchand, Jing Ma, Meir StampferVictoria L. Stevens, Dimitrios Trichopoulos, Jarmo Virtamo, Walter C. Willett, Meredith Yeager, Ann W. Hsing, Peter Kraft

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A recent genome-wide association study (GWAS) of prostate cancer in a Japanese population identified five novel regions not previously discovered in other ethnicities. In this study,weattempt to replicate these five loci in a series of nested prostate cancer case-control studies of European ancestry. Methods: We genotyped five single-nucleotide polymorphism (SNP): rs13385191 (chromosome 2p24), rs12653946 (5p15), rs1983891 (6p21), rs339331 (6p22), and rs9600079 (13q22), in 7,956 prostate cancer cases and 8,148 controls from a series of nested case-control studies within the National cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). We tested each SNP for association with prostate cancer risk and assessed whether associations differed with respect to disease severity and age of onset. Results: Four SNPs (rs13385191, rs12653946, rs1983891, and rs339331) were significantly associated with prostate cancer risk (P values ranging from 0.01 to 1.1×10 -5). Allele frequencies and ORs were overall lower in our population of European descent than in the discovery Asian population. SNP rs13385191 (C2orf43) was only associated with low-stage disease (P = 0.009, case-only test). No other SNP showed association with disease severity or age of onset. We did not replicate the 13q22 SNP, rs9600079 (P = 0.62). Conclusions: Four SNPs associated with prostate cancer risk in an Asian population are also associated with prostate cancer risk in men of European descent. Impact: This study illustrates the importance of evaluation of prostate cancer risk markers across ethnic groups.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number1
DOIs
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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