Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women

Yaping Liu, Pei Lung Chen, John McGrath, Paula Wolyniec, Daniele Daniele Fallin, Gerald Nestadt, Kung Yee Liang, Ann E Pulver, David Valle, Dimitrios Avramopoulos

Research output: Contribution to journalArticle

Abstract

A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case - control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype - phenotype correlations.

Original languageEnglish (US)
Pages (from-to)184-186
Number of pages3
JournalPsychiatric Genetics
Volume20
Issue number4
DOIs
StatePublished - Aug 2010

Fingerprint

Schizophrenia
Genes
Quantitative Trait Loci
Genetic Association Studies
Psychotic Disorders
Single Nucleotide Polymorphism
Case-Control Studies

Keywords

  • Ashkenazi
  • association
  • endophenotype
  • Jewish
  • reelin
  • schizophrenia
  • sex-specific

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Biological Psychiatry
  • Medicine(all)

Cite this

Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women. / Liu, Yaping; Chen, Pei Lung; McGrath, John; Wolyniec, Paula; Fallin, Daniele Daniele; Nestadt, Gerald; Liang, Kung Yee; Pulver, Ann E; Valle, David; Avramopoulos, Dimitrios.

In: Psychiatric Genetics, Vol. 20, No. 4, 08.2010, p. 184-186.

Research output: Contribution to journalArticle

@article{665d5b3f6b1f418abffc7f691fba5fbb,
title = "Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women",
abstract = "A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case - control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype - phenotype correlations.",
keywords = "Ashkenazi, association, endophenotype, Jewish, reelin, schizophrenia, sex-specific",
author = "Yaping Liu and Chen, {Pei Lung} and John McGrath and Paula Wolyniec and Fallin, {Daniele Daniele} and Gerald Nestadt and Liang, {Kung Yee} and Pulver, {Ann E} and David Valle and Dimitrios Avramopoulos",
year = "2010",
month = "8",
doi = "10.1097/YPG.0b013e32833a220b",
language = "English (US)",
volume = "20",
pages = "184--186",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women

AU - Liu, Yaping

AU - Chen, Pei Lung

AU - McGrath, John

AU - Wolyniec, Paula

AU - Fallin, Daniele Daniele

AU - Nestadt, Gerald

AU - Liang, Kung Yee

AU - Pulver, Ann E

AU - Valle, David

AU - Avramopoulos, Dimitrios

PY - 2010/8

Y1 - 2010/8

N2 - A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case - control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype - phenotype correlations.

AB - A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case - control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype - phenotype correlations.

KW - Ashkenazi

KW - association

KW - endophenotype

KW - Jewish

KW - reelin

KW - schizophrenia

KW - sex-specific

UR - http://www.scopus.com/inward/record.url?scp=77954887954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954887954&partnerID=8YFLogxK

U2 - 10.1097/YPG.0b013e32833a220b

DO - 10.1097/YPG.0b013e32833a220b

M3 - Article

C2 - 20431428

AN - SCOPUS:77954887954

VL - 20

SP - 184

EP - 186

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 4

ER -