Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women

Yaping Liu, Pei Lung Chen, John McGrath, Paula Wolyniec, Daniele Daniele Fallin, Gerald Nestadt, Kung Yee Liang, Ann E Pulver, David Valle, Dimitrios Avramopoulos

Research output: Contribution to journalArticle

Abstract

A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case - control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype - phenotype correlations.

Original languageEnglish (US)
Pages (from-to)184-186
Number of pages3
JournalPsychiatric Genetics
Volume20
Issue number4
DOIs
Publication statusPublished - Aug 2010

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Keywords

  • Ashkenazi
  • association
  • endophenotype
  • Jewish
  • reelin
  • schizophrenia
  • sex-specific

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Biological Psychiatry
  • Medicine(all)

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