Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women

Yaping Liu; Pei Lung Chen; John McGrath; Paula Wolyniec; Daniele Fallin; Gerald Nestadt; Kung Yee Liang; Ann Pulver; David Valle; Dimitrios Avramopoulos

doi:10.1097/YPG.0b013e32833a220b

Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women

Yaping Liu, Pei Lung Chen, John McGrath, Paula Wolyniec, Daniele Fallin, Gerald Nestadt, Kung Yee Liang, Ann Pulver, David Valle, Dimitrios Avramopoulos

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case - control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype - phenotype correlations.

Original language	English (US)
Pages (from-to)	184-186
Number of pages	3
Journal	Psychiatric genetics
Volume	20
Issue number	4
DOIs	https://doi.org/10.1097/YPG.0b013e32833a220b
State	Published - Aug 2010

Keywords

Ashkenazi
Jewish
association
endophenotype
reelin
schizophrenia
sex-specific

ASJC Scopus subject areas

Genetics
Genetics(clinical)
Psychiatry and Mental health
Biological Psychiatry

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10.1097/YPG.0b013e32833a220b

Cite this

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title = "Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women",

abstract = "A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case - control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype - phenotype correlations.",

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AU - McGrath, John

AU - Wolyniec, Paula

AU - Fallin, Daniele

AU - Nestadt, Gerald

AU - Liang, Kung Yee

AU - Pulver, Ann

AU - Valle, David

AU - Avramopoulos, Dimitrios

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Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women

Abstract

Keywords

ASJC Scopus subject areas

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