@article{7b2f827236d14ba3b61db98bf744b38e,
title = "Replication of a genome-wide association study of birth weight in preterm neonates",
abstract = "Objective: To examine associations between rs9883204 in ADCY5 and rs900400 near LEKR1 and CCNL1 with birth weight in a preterm population. Both markers were associated with birth weight in a term population in a recent genome-wide association study of Freathy et al. Study design: A meta-analysis of mother and infant samples was performed for associations of rs900400 and rs9883204 with birth weight in 393 families from the US, 265 families from Argentina, and 735 mother-infant pairs from Denmark. Z-scores adjusted for infant sex and gestational age were generated for each population separately and regressed on allele counts. Association evidence was combined across sites by inverse-variance weighted meta-analysis. Results: Each additional C allele of rs900400 (LEKR1/CCNL1) in infants was marginally associated with a 0.069 SD lower birth weight (95% CI, -0.159 to 0.022; P =.068). This result was slightly more pronounced after adjusting for smoking (P =.036). No significant associations were identified with rs9883204 or in maternal samples. Conclusions: These results indicate the potential importance of this marker on birth weight regardless of gestational age.",
author = "Ryckman, {Kelli K.} and Bjarke Feenstra and Shaffer, {John R.} and Bream, {Elise N.A.} and Frank Geller and Eleanor Feingold and Weeks, {Daniel E.} and Enrique Gadow and Viviana Cosentino and Cesar Saleme and Simhan, {Hyagriv N.} and David Merrill and Fong, {Chin To} and Tamara Busch and Berends, {Susan K.} and Belen Comas and Camelo, {Jorge L.} and Heather Boyd and Laurie, {Cathy C.} and David Crosslin and Qi Zhang and Doheny, {Kimberly F.} and Elizabeth Pugh and Mads Melbye and Marazita, {Mary L.} and Dagle, {John M.} and Murray, {Jeffrey C.}",
note = "Funding Information: We thank all of the participating families at our study sites in the US, Denmark, and Argentina. We also thank the coordinating medical and research staff at the University of Iowa Hospitals and Clinics, Magee-Women's Research Institute, Wake Forest University Baptist Medical Center, Strong Children's Research Center, Centro de Educaci{\'o}n M{\'e}dica E Investigaciones Cl{\'i}nicas, and the Instituto de Maternidad y Ginecolog{\'i}a Nuestra Se{\~n}ora de las Mercedes. Special thanks to research coordinators Laura Knosp, Kristi Lanier, Lauren Smith, and Karen Debes (funded by National Institutes of Health Grants R01 HD-52953 and R01 HD-57192 and March of Dimes Grants 1-FY05-126 and 6-FY08-260). Funding Information: Supported by the March of Dimes (Grants 1-FY05-126 and 6-FY08-260) and the National Institutes of Health (Grants R01 HD-52953 and R01 HD-57192). K.R.'s postdoctoral fellowship was supported in part by a National Institutes of Health/NRSA T-32 training grant (5T32 HL 007638-24) and a grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (K99 HD-065786). Support for the Danish National Birth Cohort was obtained from the Danish National Research Foundation, the Danish Pharmacists' Fund, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Augustinus Foundation, and the Health Fund of the Danish Health Insurance Societies. The generation of GWAS genotype data for the Danish National Birth Cohort samples was carried out within the Gene Environment Association Studies consortium with funding provided through the National Institutes of Health's Genes, Environment, and Health Initiative (U01HG004423). Assistance with phenotype harmonization, genotype cleaning, and general study coordination was provided by the Gene Environment Association Studies Coordinating Center (U01HG004446). Genotyping was performed at Johns Hopkins University Center for Inherited Disease Research, with support from the National Institutes of Health's Genes, Environment, and Health Initiative (U01HG004438). ",
year = "2012",
month = jan,
doi = "10.1016/j.jpeds.2011.07.038",
language = "English (US)",
volume = "160",
pages = "19--24.e4",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "1",
}