Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: Differences in pathogenesis map to the 3′ one-third of the genome

Sonia Navas-Martin, Maarten Brom, Ming Ming Chua, Richard Watson, Zhaozhu Qiu, Susan R. Weiss

Research output: Contribution to journalArticlepeer-review

Abstract

The important roles of the spike protein and other structural proteins in murine coronavirus (MHV) pathogenesis have been demonstrated; however, the role of the replicase gene remains unexplored. We assessed the influence of the replicase genes of the highly neurovirulent MHV-JHM strain and the hepatotropic and mildly neurovirulent A59 strain in acute infection of the mouse. Analysis of chimeric A59/JHM recombinant viruses indicates that the replicase genes are interchangeable and that it is the 3′ end of the genome, encoding the structural proteins, rather than the replicase gene, that determines the pathogenic properties of these chimeras.

Original languageEnglish (US)
Pages (from-to)1022-1026
Number of pages5
JournalJournal of virology
Volume81
Issue number2
DOIs
StatePublished - Jan 2007
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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