Reperfusion of specific cortical areas is associated with improvement in distinct forms of hemispatial neglect

Shaan Khurshid, Lydia A. Trupe, Melissa Newhart, Cameron Davis, John J. Molitoris, Jared Medina, Richard Leigh, Argye E. Hillis

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: To test the hypothesis that restoring blood flow to specific right cortical regions in acute stroke results in improvement in distinct forms of hemispatial neglect distinguished by reference frame: viewer-centered versus stimulus-centered neglect. Methods: Twenty five patients with acute right stroke were evaluated at Day 1 and Day 3-5 with a battery of neglect tests and Diffusion- and Perfusion-Weighted MR Imaging. Multivariate linear regression analysis revealed Brodmann areas (BAs) where reperfusion predicted degree of improvement in scores on each type of neglect, independently of reperfusion of other areas, total change in the volume of infarct or hypoperfusion, and age. Results: Reperfusion of dorsal frontoparietal cortex (including BAs 40, 46, and 4) independently predicted improvement in viewer-centered neglect, such as detecting stimuli on left in line cancellation and scene copying (r= .951; p< .0001). Reperfusion of a more ventral temporo-occipital cortex, including right BAs 37, 38, 21 and 18, independently contributed to improvement in stimulus-centered neglect, such as detecting left gaps in circles (r= .926; p< .0001). Reperfusion of right midfusiform gyrus (temporal occipital cortex), change in total volume of ischemia, change in volume of hypoperfusion and age predicted degree of improvement in reading (reduction in "neglect dyslexic" errors; r= .915; p< .0001). Results demonstrate that reperfusing specific cortical regions yields improvement in different types of neglect.

Original languageEnglish (US)
Pages (from-to)530-539
Number of pages10
Issue number5
StatePublished - May 2012


  • Acute stroke
  • Hemispatial neglect
  • Reperfusion

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


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