Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain

Alistair Young; Brent French; Zequan Yang; Brett Cowan; Wesley Gilson; Stuart Berr; Christopher Kramer; Frederick Epstein

doi:10.1080/10976640600721767

Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain

Alistair Young, Brent French, Zequan Yang, Brett Cowan, Wesley Gilson, Stuart Berr, Christopher Kramer, Frederick Epstein

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We developed mathematical modeling tools for mapping 3D infarct geometry from multislice late gadolinium enhancement data, allowing fusion with multislice MR tagging data, in mice with myocardial infarction. Five C57BL/6 mice were imaged at baseline, 1, 7 and 28 days after 60 min occlusion of the left anterior descending coronary artery. The 3D infarct geometry was mapped in material coordinates, and registered with 3D strain, showing permanent dysfunction in infarcted segments, intermediate function in the adjacent zone, and maintained function in the remote zone. 3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework.

Original language	English (US)
Pages (from-to)	685-692
Number of pages	8
Journal	Journal of Cardiovascular Magnetic Resonance
Volume	8
Issue number	5
DOIs	https://doi.org/10.1080/10976640600721767
State	Published - Oct 1 2006
Externally published	Yes

Keywords

Data Fusion
Late Gadolinium Enhancement
Myocardial Infarction
Myocardial Strain
Ventricular Remodeling

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology
Family Practice

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10.1080/10976640600721767

Cite this

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abstract = "We developed mathematical modeling tools for mapping 3D infarct geometry from multislice late gadolinium enhancement data, allowing fusion with multislice MR tagging data, in mice with myocardial infarction. Five C57BL/6 mice were imaged at baseline, 1, 7 and 28 days after 60 min occlusion of the left anterior descending coronary artery. The 3D infarct geometry was mapped in material coordinates, and registered with 3D strain, showing permanent dysfunction in infarcted segments, intermediate function in the adjacent zone, and maintained function in the remote zone. 3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework.",

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AU - Young, Alistair

AU - French, Brent

AU - Yang, Zequan

AU - Cowan, Brett

AU - Gilson, Wesley

AU - Berr, Stuart

AU - Kramer, Christopher

AU - Epstein, Frederick

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KW - Late Gadolinium Enhancement

KW - Myocardial Infarction

KW - Myocardial Strain

KW - Ventricular Remodeling

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Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain

Abstract

Keywords

ASJC Scopus subject areas

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