Reperfused myocardial infarction in mice: 3D mapping of late gadolinium enhancement and strain

Alistair Young, Brent French, Zequan Yang, Brett Cowan, Wesley Gilson, Stuart Berr, Christopher Kramer, Frederick Epstein

Research output: Contribution to journalArticle

Abstract

We developed mathematical modeling tools for mapping 3D infarct geometry from multislice late gadolinium enhancement data, allowing fusion with multislice MR tagging data, in mice with myocardial infarction. Five C57BL/6 mice were imaged at baseline, 1, 7 and 28 days after 60 min occlusion of the left anterior descending coronary artery. The 3D infarct geometry was mapped in material coordinates, and registered with 3D strain, showing permanent dysfunction in infarcted segments, intermediate function in the adjacent zone, and maintained function in the remote zone. 3D mapping of late enhancement and strain allows registration of multiple studies in a consistent framework.

Original languageEnglish (US)
Pages (from-to)685-692
Number of pages8
JournalJournal of Cardiovascular Magnetic Resonance
Volume8
Issue number5
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

    Fingerprint

Keywords

  • Data Fusion
  • Late Gadolinium Enhancement
  • Myocardial Infarction
  • Myocardial Strain
  • Ventricular Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice

Cite this