TY - JOUR
T1 - Repeated exposures of the male Sprague Dawley rat reproductive tract to environmental toxicants
T2 - Do earlier exposures to di-(2-ethylhexyl)phthalate (DEHP) alter the effects of later exposures?
AU - Traore, Kassim
AU - Martinez-Arguelles, Daniel B.
AU - Papadopoulos, Vassilios
AU - Chen, Haolin
AU - Zirkin, Barry R.
N1 - Funding Information:
This work was supported by NIH grants SC2 GM099578 (KT) and R37 AG021092 (BZ) , CIHR grant MOP-111131 (VP) , and a Canada Research Chair in Biochemical Pharmacology (VP).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Although exposures to environmental toxicants occur throughout life, little attention has been paid to the possible effects of exposures early in life on later exposure effects. We asked whether DEHP administered in utero (GD14-parturition) affects how male rats respond to later exposures. Neither in utero nor juvenile (PND21-35) exposures to 100 mg/kg/day DEHP affected testis weight or histology as assessed on PND35. However, after in utero DEHP, subsequent juvenile exposure resulted in significantly reduced testis weight and altered testicular histology. Both in utero and juvenile exposures resulted in significant reductions in serum testosterone, but there was no effect of earlier on later exposure. Whether or not there had been in utero DEHP exposure, juvenile DEHP exposure had no effect on body, kidney or liver weights. These observations indicate that in utero exposure can, but will not necessarily, alter later exposure effects, with outcomes dependent upon endpoints measured and dose.
AB - Although exposures to environmental toxicants occur throughout life, little attention has been paid to the possible effects of exposures early in life on later exposure effects. We asked whether DEHP administered in utero (GD14-parturition) affects how male rats respond to later exposures. Neither in utero nor juvenile (PND21-35) exposures to 100 mg/kg/day DEHP affected testis weight or histology as assessed on PND35. However, after in utero DEHP, subsequent juvenile exposure resulted in significantly reduced testis weight and altered testicular histology. Both in utero and juvenile exposures resulted in significant reductions in serum testosterone, but there was no effect of earlier on later exposure. Whether or not there had been in utero DEHP exposure, juvenile DEHP exposure had no effect on body, kidney or liver weights. These observations indicate that in utero exposure can, but will not necessarily, alter later exposure effects, with outcomes dependent upon endpoints measured and dose.
KW - Di-(2-ethylhexyl)phthalate (DEHP)
KW - Endocrine disruptors
KW - Environmental toxicants
KW - Leydig cells
KW - Testosterone
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U2 - 10.1016/j.reprotox.2016.03.046
DO - 10.1016/j.reprotox.2016.03.046
M3 - Article
C2 - 27040317
AN - SCOPUS:84962713053
SN - 0890-6238
VL - 61
SP - 136
EP - 141
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -