Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI

Andrew D. Levy, Qian Li, Maria C. Alvarez Sanz, Peter A. Rittenhouse, Mark S. Brownfield, Louis D. Van de Kar

Research output: Contribution to journalArticle

Abstract

Endocrine responses to the serotonin (5-HT) 5-HTic(-/5-HT2 agonist (±)-l-(2,5-dimcthoxy-4-iodophenyl)-2-aminopropane (DOI) were utilised to evaluate cocaine-induced alterations in postsynaptic 5-HT receptor function. Rats received cocaine HC1 (0, 5 or 15 mg/kg i.p.) twice daily for 7 days. Effects of DOI (0, 0.5, 2 or 10 mg/kg i.p.) on plasma adrenocorticotropic hormone (ACTH), corticosterone, prolactin, oxytocin and renin concentrations were assessed 42 h after the final cocaine injection. DOI dose dcpcndcntly increased the plasma concentrations of each hormone. Cocaine potentiated the DOI-induced elevations of plasma ACTH, corticostcrone and prolactin concentrations. In contrast, the oxytocin response was reduced, and the renin response was unaltered by cocaine exposure. The data suggest that 5-HT2 receptor-mediated responses for ACTH, corticosterone and prolactin secretion become superscnsitivc following repeated cocaine. In contrast, the 5-HT2, receptor-mediated response for oxytocin secretion is subscnsitive. The cocaine-induced changes in posisynaptic 5-HT receptor function are likely a consequence of deficits in the function of 5-HT nerve terminals, that we have documented previously.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalEuropean Journal of Pharmacology
Volume221
Issue number1
DOIs
StatePublished - Oct 6 1992
Externally publishedYes

Fingerprint

Serotonin 5-HT2 Receptor Agonists
Cocaine
Oxytocin
Prolactin
Adrenocorticotropic Hormone
Serotonin
Serotonin Receptors
Corticosterone
Renin
Hormones
Injections

Keywords

  • 5-HT (5-hydroxytryptaminc, serolonin)
  • ACTH (adrcnocorticotropic hormone)
  • Cocaine
  • Oxytocin
  • Prolactin
  • Renin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Levy, A. D., Li, Q., Alvarez Sanz, M. C., Rittenhouse, P. A., Brownfield, M. S., & Van de Kar, L. D. (1992). Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI. European Journal of Pharmacology, 221(1), 121-127. https://doi.org/10.1016/0014-2999(92)90780-8

Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI. / Levy, Andrew D.; Li, Qian; Alvarez Sanz, Maria C.; Rittenhouse, Peter A.; Brownfield, Mark S.; Van de Kar, Louis D.

In: European Journal of Pharmacology, Vol. 221, No. 1, 06.10.1992, p. 121-127.

Research output: Contribution to journalArticle

Levy, AD, Li, Q, Alvarez Sanz, MC, Rittenhouse, PA, Brownfield, MS & Van de Kar, LD 1992, 'Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI', European Journal of Pharmacology, vol. 221, no. 1, pp. 121-127. https://doi.org/10.1016/0014-2999(92)90780-8
Levy, Andrew D. ; Li, Qian ; Alvarez Sanz, Maria C. ; Rittenhouse, Peter A. ; Brownfield, Mark S. ; Van de Kar, Louis D. / Repeated cocaine modifies the neuroendocrine responses to the 5-HT1C/5-HT2 receptor agonist DOI. In: European Journal of Pharmacology. 1992 ; Vol. 221, No. 1. pp. 121-127.
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