Repeatability of radiotracer uptake in normal abdominal organs with 111In-pentetreotide quantitative SPECT/CT

Steven P. Rowe, Esther Vicente, Nadège Anizan, Hao Wang, Jeffrey P. Leal, Martin A. Lodge, Eric C. Frey, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

With an increasing emphasis on quantitation of SPECT imaging and its use in dosimetry to guide therapies, it is desirable to understand the repeatability in normal-organ SPECT uptake values (SPECTUVs). We investigated the variability of normal abdominal organ uptake in repeated 111In-pentetreotide SPECT studies. Methods: Nine patients with multiple 111In-pentetreotide SPECT/CT studies for clinical purposes were evaluated. Volumes of interest were drawn for the abdominal organs and applied to SPECT-UVs. The variability of those values was assessed. Results: The average SPECT-UV for the liver (1.7 ± 0.6) was much lower than for the kidneys (right, 8.0 ± 2.4; left, 7.5 ± 1.7). Interpatient and intrapatient variability was similar (intraclass correlation coefficients, 0.40-0.59) for all organs. The average coefficients of variation for each organ for each patient were obtained and averaged across all patients (0.26 for liver, 0.22 for right kidney, and 0.20 for left kidney). The coefficients of variation for the organs across all scans were 0.33 (liver), 0.30 (right kidney), and 0.22 (left kidney). Conclusion: Variability across all patients and all scans for the liver was higher than reported with 18F-FDG PET, though left kidney variability was similar to PET liver variability and left kidney uptake may be able to serve as an internal metric for determining the quantifiability of an 111In-pentetreotide SPECT study.

Original languageEnglish (US)
Pages (from-to)985-988
Number of pages4
JournalJournal of Nuclear Medicine
Volume56
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Dosimetry
  • In-pentetreotide SPECT
  • Quantitative SPECT
  • SPECT-UV

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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