Repeat revaccination with 23-valent pneumococcal polysaccharide vaccine among adults aged 55-74 years living in Alaska: No evidence of hyporesponsiveness

Laura L. Hammitt, Lisa R. Bulkow, Rosalyn J. Singleton, J. Pekka Nuorti, Kim Boyd Hummel, Karen M. Miernyk, Carolyn Zanis, Melissa Whaley, Sandra Romero-Steiner, Jay C. Butler, Karen Rudolph, Thomas W. Hennessy

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Older adults are at highest risk of invasive pneumococcal disease (IPD) and are recommended to receive vaccination with 23-valent pneumococcal polysaccharide vaccine (PPV23). Antibody concentrations decline following vaccination. We evaluated the immunogenicity and reactogenicity of revaccination and repeat revaccination. Methods: Adults aged 55-74 years were vaccinated with a 1st to 4th dose of PPV23. Participants were eligible for revaccination if a minimum of 6 years had passed since their last dose of PPV23. Blood collected on the day of vaccination and 30 days later was analyzed by ELISA for IgG to five serotypes. Functional antibody activity was measured using an opsonophagocytic killing (OPK) assay. Reactions to vaccination were documented. Results: Subjects were vaccinated with a 1st dose (n= 123), 2nd dose (n= 121), or 3rd or 4th dose (n= 71) of PPV23. The post-vaccination IgG geometric mean concentrations (GMCs) were similar among first-time vaccinees and re-vaccinees for all serotypes with the exception of a lower GMC for serotype 1 in re-vaccinees. The post-vaccination OPK geometric mean titers (GMTs) were similar among first-time vaccinees and re-vaccinees with the exception of a higher GMT for serotype 6B in re-vaccinees. Compared to first-time vaccinees, re-vaccinees reported more joint pain (p= 0.004), fatigue (p= 0.019), headache (p= 0.014), swelling (p= 0.006), and moderate limitation in arm movement (p= 0.025). Conclusions: Repeat revaccination with PPV23, administered 6 or more years after the prior dose, was immunogenic and generally well tolerated.

Original languageEnglish (US)
Pages (from-to)2287-2295
Number of pages9
JournalVaccine
Volume29
Issue number12
DOIs
StatePublished - Jan 31 2011
Externally publishedYes

Keywords

  • Hyporesponsiveness
  • Immunogenicity
  • Opsonophagocytosis
  • Pneumococcal polysaccharide vaccine
  • Revaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Repeat revaccination with 23-valent pneumococcal polysaccharide vaccine among adults aged 55-74 years living in Alaska: No evidence of hyporesponsiveness'. Together they form a unique fingerprint.

Cite this