Repair of articular cartilage and meniscal tears by photoactive dyes: in-vivo study

Millard M. Judy, Robert W M D Jackson, Hany R M D Nosir, James Lester Matthews, David E. Lewis, Ronald E. Utecht, Dongwu Yuan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We describe healing results of our 6 month study of a repair procedure which evokes the healing response in meniscal tears and partial thickness defects in articular cartilage by a non-thermal tissue sparing photochemical weld using 1,8-naphthalimide dyes. Welds of incisional flaps in adult sheep meniscus and femoral articular cartilage were made using the dye MBM Gold 012011012 at 12 mM in PBS, 457.9nm Argon ion laser radiation at 800 mW/cm 2, 7.5 minutes with approximately 1 kg/cm 2 externally applied pressure. Gross appearance of tissues in all welded knees appeared normal. Hematoxylin and eosin stained sections disclosed close bonding of welded areas and continuing healing response as cellular recruitment.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsFrederic Laffitte, Raimund Hibst, Hans-Dieter Reidenbach, Herbert J. Geschwind, Giulio Maira, et.al.
Pages436-440
Number of pages5
Volume2922
Publication statusPublished - 1996
Externally publishedYes
EventLaser Applications in Medicine and Dentistry - Vienna, Austria
Duration: Sep 7 1996Sep 10 1996

Other

OtherLaser Applications in Medicine and Dentistry
CityVienna, Austria
Period9/7/969/10/96

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Judy, M. M., Jackson, R. W. M. D., Nosir, H. R. M. D., Matthews, J. L., Lewis, D. E., Utecht, R. E., & Yuan, D. (1996). Repair of articular cartilage and meniscal tears by photoactive dyes: in-vivo study. In F. Laffitte, R. Hibst, H-D. Reidenbach, H. J. Geschwind, G. Maira, & et.al. (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2922, pp. 436-440)