Renal responses to central vascular expansion are suppressed at night in conscious primates

D. A. Kass, F. M. Sulzman, C. A. Fuller, M. C. Moore-Ede

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2 Scopus citations


Renal and hemodynamic responses to central vascular volume expansion induced by 4 h of continuous lower body positive air pressure (LBPP) were examined in conscious, chair-restrained squirrel monkeys in a light/dark (12:12) cycle. LBPP (30 mmHg) during both day (1200-1600) and night (0000-0400) induced similar 4 cmH2O stable increases in central venous pressure (P<0.001), rises in heart rate of 25 beat/min (P<0.001), and small transient elevations in mean arterial blood pressure. In contrast, while daytime LBPP induced a significant increase in urine flow (V) from 2.12±0.31 to 3.5±0.42 ml/h (P<0.05), and sodium excretion (U(Na)V) from 71.1±14 to 271.2±37 μeq/h (P<0.001), there was a marked nocturnal inhibition of the response to LBPP, with no significant increases in V or U(Na)V. Urine osmolality decreased by more than 50% at both times of pressure exposure; potassium excretion was not significantly affected by either exposure, and drinking was suppressed during daytime LBPP. Comparisons of the time course and diurnal regulation of the urinary responses suggest that several separate efferent control pathways are involved.

Original languageEnglish (US)
Pages (from-to)F343-F351
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Issue number4
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Physiology


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