Renal Parenchymal Area Growth Curves for Children 0 to 10 Months Old

Katherine Fischer, Chunming Li, Huixuan Wang, Yihua Song, Susan Furth, Gregory E. Tasian

Research output: Contribution to journalArticle

Abstract

Purpose: Low renal parenchymal area, which is the gross area of the kidney in maximal longitudinal length minus the area of the collecting system, has been associated with increased risk of end stage renal disease during childhood in boys with posterior urethral valves. To our knowledge normal values do not exist. We aimed to increase the clinical usefulness of this measure by defining normal renal parenchymal area during infancy. Materials and Methods: In a cross-sectional study of children with prenatally detected mild unilateral hydronephrosis who were evaluated between 2000 and 2012 we measured the renal parenchymal area of normal kidney(s) opposite the kidney with mild hydronephrosis. Measurement was done with ultrasound from birth to post-gestational age 10 months. We used the LMS method to construct unilateral, bilateral, side and gender stratified normalized centile curves. We determined the z-score and the centile of a total renal parenchymal area of 12.4 cm2 at post-gestational age 1 to 2 weeks, which has been associated with an increased risk of kidney failure before age 18 years in boys with posterior urethral valves. Results: A total of 975 normal kidneys of children 0 to 10 months old were used to create renal parenchymal area centile curves. At the 97th centile for unilateral and single stratified curves the estimated margin of error was 4.4% to 8.8%. For bilateral and double stratified curves the estimated margin of error at the 97th centile was 6.6% to 13.2%. Total renal parenchymal area less than 12.4 cm2 at post-gestational age 1 to 2 weeks had a z-score of -1.96 and fell at the 3rd percentile. Conclusions: These normal renal parenchymal area curves may be used to track kidney growth in infants and identify those at risk for chronic kidney disease progression.

Original languageEnglish (US)
JournalJournal of Urology
DOIs
StateAccepted/In press - 2016
Externally publishedYes

Fingerprint

Kidney
Growth
Gestational Age
Hydronephrosis
Chronic Renal Insufficiency
Chronic Kidney Failure
Renal Insufficiency
Disease Progression
Reference Values
Cross-Sectional Studies
Parturition

Keywords

  • Abnormalities
  • Chronic
  • Kidney
  • Organ size
  • Renal insufficiency
  • Ultrasonography

ASJC Scopus subject areas

  • Urology

Cite this

Fischer, K., Li, C., Wang, H., Song, Y., Furth, S., & Tasian, G. E. (Accepted/In press). Renal Parenchymal Area Growth Curves for Children 0 to 10 Months Old. Journal of Urology. https://doi.org/10.1016/j.juro.2015.08.097

Renal Parenchymal Area Growth Curves for Children 0 to 10 Months Old. / Fischer, Katherine; Li, Chunming; Wang, Huixuan; Song, Yihua; Furth, Susan; Tasian, Gregory E.

In: Journal of Urology, 2016.

Research output: Contribution to journalArticle

Fischer, Katherine ; Li, Chunming ; Wang, Huixuan ; Song, Yihua ; Furth, Susan ; Tasian, Gregory E. / Renal Parenchymal Area Growth Curves for Children 0 to 10 Months Old. In: Journal of Urology. 2016.
@article{0dd02b6f166443a4a9d620459b9c3c0e,
title = "Renal Parenchymal Area Growth Curves for Children 0 to 10 Months Old",
abstract = "Purpose: Low renal parenchymal area, which is the gross area of the kidney in maximal longitudinal length minus the area of the collecting system, has been associated with increased risk of end stage renal disease during childhood in boys with posterior urethral valves. To our knowledge normal values do not exist. We aimed to increase the clinical usefulness of this measure by defining normal renal parenchymal area during infancy. Materials and Methods: In a cross-sectional study of children with prenatally detected mild unilateral hydronephrosis who were evaluated between 2000 and 2012 we measured the renal parenchymal area of normal kidney(s) opposite the kidney with mild hydronephrosis. Measurement was done with ultrasound from birth to post-gestational age 10 months. We used the LMS method to construct unilateral, bilateral, side and gender stratified normalized centile curves. We determined the z-score and the centile of a total renal parenchymal area of 12.4 cm2 at post-gestational age 1 to 2 weeks, which has been associated with an increased risk of kidney failure before age 18 years in boys with posterior urethral valves. Results: A total of 975 normal kidneys of children 0 to 10 months old were used to create renal parenchymal area centile curves. At the 97th centile for unilateral and single stratified curves the estimated margin of error was 4.4{\%} to 8.8{\%}. For bilateral and double stratified curves the estimated margin of error at the 97th centile was 6.6{\%} to 13.2{\%}. Total renal parenchymal area less than 12.4 cm2 at post-gestational age 1 to 2 weeks had a z-score of -1.96 and fell at the 3rd percentile. Conclusions: These normal renal parenchymal area curves may be used to track kidney growth in infants and identify those at risk for chronic kidney disease progression.",
keywords = "Abnormalities, Chronic, Kidney, Organ size, Renal insufficiency, Ultrasonography",
author = "Katherine Fischer and Chunming Li and Huixuan Wang and Yihua Song and Susan Furth and Tasian, {Gregory E.}",
year = "2016",
doi = "10.1016/j.juro.2015.08.097",
language = "English (US)",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Renal Parenchymal Area Growth Curves for Children 0 to 10 Months Old

AU - Fischer, Katherine

AU - Li, Chunming

AU - Wang, Huixuan

AU - Song, Yihua

AU - Furth, Susan

AU - Tasian, Gregory E.

PY - 2016

Y1 - 2016

N2 - Purpose: Low renal parenchymal area, which is the gross area of the kidney in maximal longitudinal length minus the area of the collecting system, has been associated with increased risk of end stage renal disease during childhood in boys with posterior urethral valves. To our knowledge normal values do not exist. We aimed to increase the clinical usefulness of this measure by defining normal renal parenchymal area during infancy. Materials and Methods: In a cross-sectional study of children with prenatally detected mild unilateral hydronephrosis who were evaluated between 2000 and 2012 we measured the renal parenchymal area of normal kidney(s) opposite the kidney with mild hydronephrosis. Measurement was done with ultrasound from birth to post-gestational age 10 months. We used the LMS method to construct unilateral, bilateral, side and gender stratified normalized centile curves. We determined the z-score and the centile of a total renal parenchymal area of 12.4 cm2 at post-gestational age 1 to 2 weeks, which has been associated with an increased risk of kidney failure before age 18 years in boys with posterior urethral valves. Results: A total of 975 normal kidneys of children 0 to 10 months old were used to create renal parenchymal area centile curves. At the 97th centile for unilateral and single stratified curves the estimated margin of error was 4.4% to 8.8%. For bilateral and double stratified curves the estimated margin of error at the 97th centile was 6.6% to 13.2%. Total renal parenchymal area less than 12.4 cm2 at post-gestational age 1 to 2 weeks had a z-score of -1.96 and fell at the 3rd percentile. Conclusions: These normal renal parenchymal area curves may be used to track kidney growth in infants and identify those at risk for chronic kidney disease progression.

AB - Purpose: Low renal parenchymal area, which is the gross area of the kidney in maximal longitudinal length minus the area of the collecting system, has been associated with increased risk of end stage renal disease during childhood in boys with posterior urethral valves. To our knowledge normal values do not exist. We aimed to increase the clinical usefulness of this measure by defining normal renal parenchymal area during infancy. Materials and Methods: In a cross-sectional study of children with prenatally detected mild unilateral hydronephrosis who were evaluated between 2000 and 2012 we measured the renal parenchymal area of normal kidney(s) opposite the kidney with mild hydronephrosis. Measurement was done with ultrasound from birth to post-gestational age 10 months. We used the LMS method to construct unilateral, bilateral, side and gender stratified normalized centile curves. We determined the z-score and the centile of a total renal parenchymal area of 12.4 cm2 at post-gestational age 1 to 2 weeks, which has been associated with an increased risk of kidney failure before age 18 years in boys with posterior urethral valves. Results: A total of 975 normal kidneys of children 0 to 10 months old were used to create renal parenchymal area centile curves. At the 97th centile for unilateral and single stratified curves the estimated margin of error was 4.4% to 8.8%. For bilateral and double stratified curves the estimated margin of error at the 97th centile was 6.6% to 13.2%. Total renal parenchymal area less than 12.4 cm2 at post-gestational age 1 to 2 weeks had a z-score of -1.96 and fell at the 3rd percentile. Conclusions: These normal renal parenchymal area curves may be used to track kidney growth in infants and identify those at risk for chronic kidney disease progression.

KW - Abnormalities

KW - Chronic

KW - Kidney

KW - Organ size

KW - Renal insufficiency

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=84975705185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975705185&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2015.08.097

DO - 10.1016/j.juro.2015.08.097

M3 - Article

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

ER -