Renal function, erythropoietin, and anemia of older persons: The InCHIANTI study

Alessandro Ble; Jeffrey C. Fink; Richard C. Woodman; Mark A. Klausner; B. Gwen Windham; Jack M. Guralnik; Luigi Ferrucci

doi:10.1001/archinte.165.19.2222

Renal function, erythropoietin, and anemia of older persons: The InCHIANTI study

Alessandro Ble, Jeffrey C. Fink, Richard C. Woodman, Mark A. Klausner, B. Gwen Windham, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Background: In the older population, anemia has been associated with poor outcomes including disability and mortality. Understanding the mechanisms leading to anemia is essential to plan better treatment and prevention strategies. We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels. Methods: Data were from the InCHIANTI study, a population-based study performed in a sample of community-dwelling older (≥65 years) persons living in Italy. This analysis included 1005 participants with complete data on hemoglobin and erythropoietin levels and markers of renal function. Results: The prevalence of anemia according to the World Health Organization criteria (hemoglobin level 1.50 mL/s) (P

Original language	English (US)
Pages (from-to)	2222-2227
Number of pages	6
Journal	Archives of Internal Medicine
Volume	165
Issue number	19
DOIs	https://doi.org/10.1001/archinte.165.19.2222
State	Published - Oct 24 2005
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

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title = "Renal function, erythropoietin, and anemia of older persons: The InCHIANTI study",

abstract = "Background: In the older population, anemia has been associated with poor outcomes including disability and mortality. Understanding the mechanisms leading to anemia is essential to plan better treatment and prevention strategies. We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels. Methods: Data were from the InCHIANTI study, a population-based study performed in a sample of community-dwelling older (≥65 years) persons living in Italy. This analysis included 1005 participants with complete data on hemoglobin and erythropoietin levels and markers of renal function. Results: The prevalence of anemia according to the World Health Organization criteria (hemoglobin level 1.50 mL/s) (P",

author = "Alessandro Ble and Fink, {Jeffrey C.} and Woodman, {Richard C.} and Klausner, {Mark A.} and Windham, {B. Gwen} and Guralnik, {Jack M.} and Luigi Ferrucci",

year = "2005",

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T1 - Renal function, erythropoietin, and anemia of older persons

T2 - The InCHIANTI study

AU - Ble, Alessandro

AU - Fink, Jeffrey C.

AU - Woodman, Richard C.

AU - Klausner, Mark A.

AU - Windham, B. Gwen

AU - Guralnik, Jack M.

AU - Ferrucci, Luigi

PY - 2005/10/24

Y1 - 2005/10/24

N2 - Background: In the older population, anemia has been associated with poor outcomes including disability and mortality. Understanding the mechanisms leading to anemia is essential to plan better treatment and prevention strategies. We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels. Methods: Data were from the InCHIANTI study, a population-based study performed in a sample of community-dwelling older (≥65 years) persons living in Italy. This analysis included 1005 participants with complete data on hemoglobin and erythropoietin levels and markers of renal function. Results: The prevalence of anemia according to the World Health Organization criteria (hemoglobin level 1.50 mL/s) (P

AB - Background: In the older population, anemia has been associated with poor outcomes including disability and mortality. Understanding the mechanisms leading to anemia is essential to plan better treatment and prevention strategies. We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels. Methods: Data were from the InCHIANTI study, a population-based study performed in a sample of community-dwelling older (≥65 years) persons living in Italy. This analysis included 1005 participants with complete data on hemoglobin and erythropoietin levels and markers of renal function. Results: The prevalence of anemia according to the World Health Organization criteria (hemoglobin level 1.50 mL/s) (P

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Renal function, erythropoietin, and anemia of older persons: The InCHIANTI study

Abstract

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