Glomerular filtration rate (GFR) was increased, and urine flow rate and sodium excretion diminished early in painful sickle cell crisis; the last two changes may be responses to a tendency to shrinkage of plasma volume. Increased GFR during painful crisis could in the presence of decreased fluid intake contribute to fluid loss, loss of plasma volume and circulatory stasis.
|Original language||English (US)|
|Number of pages||6|
|Journal||West Indian Medical Journal|
|State||Published - 1975|
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