Renal function and lithium: A longitudinal study

J. R. DePaulo, E. I. Correa, D. G. Sapir

Research output: Contribution to journalArticlepeer-review


Forty lithium-treated manic-depressive patients underwent two renal function assessments 6 to 18 months apart to assess the course of renal function changes associated with lithium therapy. No change in glomerular filtration rate was noted. Although the average 24-hour urine volume increased significantly, large increases occurred in few patients. Most patients had no substantial urine volume change, and a few had decreases. The changes were correlated with serum lithium levels. The results suggest that the majority of patients develop little renal concentrating impairment, while a small proportion of patients become more polyuric with further lithium treatment.

Original languageEnglish (US)
Pages (from-to)892-895
Number of pages4
JournalAmerican Journal of Psychiatry
Issue number7
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Psychiatry and Mental health


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