Renal dysfunction in children with uncomplicated, Plasmodium falciparum malaria in Tamale, Ghana

G. D. Burchard, S. Ehrhardt, F. P. Mockenhaupt, A. Mathieu, P. Agana-Nsiire, S. D. Anemana, R. N. Otchwemah, W. Abel, N. Brattig

Research output: Contribution to journalArticlepeer-review

Abstract

In a study performed in Tamale, in the Northern region of Ghana, cystatin C, a new and sensitive indicator of the glomerular filtration rate (GFR), was used to estimate the frequency of renal dysfunction in 78 children with uncomplicated, Plasmodium falciparum malaria. The excretion in urine of albumin, immunoglobulin G and α1-microglobulin was also investigated. Plasma concentrations of cystatin C were found to be elevated in 17% of the children, indicating subclinical impairment of renal function. As most (85%) of the children had glomerular as well as tubular patterns of proteinuria, it appears that both glomerulonephritis and damage to tubular cells often occur in P. falciparum malaria.

Original languageEnglish (US)
Pages (from-to)345-350
Number of pages6
JournalAnnals of tropical medicine and parasitology
Volume97
Issue number4
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Renal dysfunction in children with uncomplicated, Plasmodium falciparum malaria in Tamale, Ghana'. Together they form a unique fingerprint.

Cite this