Renal cell carcinoma associated with prominent angioleiomyoma-like proliferation: Report of 5 cases and review of the literature

Elisabetta Kuhn, Jazmìn De Anda, Samanta Manoni, George Netto, Juan Rosai

Research output: Contribution to journalArticle


Five cases of renal cell carcinoma of clear cell type are presented, Fuhrmann's grade 2, associated with a peculiar stromal proliferation having angioleiomyoma-like features. This proliferation was particularly prominent at the interphase between the tumor edge and the surrounding normal tissues, in which it acquired the configuration of a tumor capsule. Four similar cases were taken from the literature. We postulate that this angioleiomyoma-like change is a tumor epiphenomenon and that it represents yet another manifestation of the well-documented capacity of renal cell carcinoma to induce vascular proliferation, probably through the secretion of angiogenic and other growth factors by the tumor cells.

Original languageEnglish (US)
Pages (from-to)1372-1381
Number of pages10
JournalAmerican Journal of Surgical Pathology
Issue number11
StatePublished - Nov 1 2006



  • Angiogenic factors
  • Angioleiomyoma
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this