Renal cell carcinoma associated with prominent angioleiomyoma-like proliferation

Report of 5 cases and review of the literature

Elisabetta Kuhn, Jazmìn De Anda, Samanta Manoni, George Netto, Juan Rosai

Research output: Contribution to journalArticle

Abstract

Five cases of renal cell carcinoma of clear cell type are presented, Fuhrmann's grade 2, associated with a peculiar stromal proliferation having angioleiomyoma-like features. This proliferation was particularly prominent at the interphase between the tumor edge and the surrounding normal tissues, in which it acquired the configuration of a tumor capsule. Four similar cases were taken from the literature. We postulate that this angioleiomyoma-like change is a tumor epiphenomenon and that it represents yet another manifestation of the well-documented capacity of renal cell carcinoma to induce vascular proliferation, probably through the secretion of angiogenic and other growth factors by the tumor cells.

Original languageEnglish (US)
Pages (from-to)1372-1381
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number11
DOIs
StatePublished - Nov 2006

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Angiomyoma
Renal Cell Carcinoma
Neoplasms
Interphase
Capsules
Blood Vessels
Intercellular Signaling Peptides and Proteins

Keywords

  • Angiogenic factors
  • Angioleiomyoma
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Renal cell carcinoma associated with prominent angioleiomyoma-like proliferation : Report of 5 cases and review of the literature. / Kuhn, Elisabetta; De Anda, Jazmìn; Manoni, Samanta; Netto, George; Rosai, Juan.

In: American Journal of Surgical Pathology, Vol. 30, No. 11, 11.2006, p. 1372-1381.

Research output: Contribution to journalArticle

Kuhn, Elisabetta ; De Anda, Jazmìn ; Manoni, Samanta ; Netto, George ; Rosai, Juan. / Renal cell carcinoma associated with prominent angioleiomyoma-like proliferation : Report of 5 cases and review of the literature. In: American Journal of Surgical Pathology. 2006 ; Vol. 30, No. 11. pp. 1372-1381.
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