Renal adaptation to phosphate load in the acutely thyroparathyroidectomized rat: Rapid alteration in brush border membrane phosphate transport

L. Cheng, C. Dersch, E. Kraus

Research output: Contribution to journalArticlepeer-review

Abstract

The sustained in vivo infusion of phosphate into thyroparathyroidectomized rats resulted, after 1 h, in a marked decrease in net phosphate reabsorption, even though the plasma concentration of phosphate continued to rise. This response to phosphate infusion was expressed at the level of the proximal tubule brush border membrane. Within 40 min of the initiation of the infusion the Na+-dependent phosphate uptake system in isolated membrane vesicles was decreased. Phosphate uptake in the absence of Na+, Na+-dependent D-glucose uptake, and 22Na+ uptake were not affected. These findings demonstrate the locus of this parathyroid hormone-independent adaptation and indicate the rapidity with which the membrane transport system is regulated.

Original languageEnglish (US)
Pages (from-to)F488-F494
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume15
Issue number4
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Physiology

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