TY - JOUR
T1 - Renal adaptation to phosphate load in the acutely thyroparathyroidectomized rat
T2 - Rapid alteration in brush border membrane phosphate transport
AU - Cheng, L.
AU - Dersch, C.
AU - Kraus, E.
PY - 1984
Y1 - 1984
N2 - The sustained in vivo infusion of phosphate into thyroparathyroidectomized rats resulted, after 1 h, in a marked decrease in net phosphate reabsorption, even though the plasma concentration of phosphate continued to rise. This response to phosphate infusion was expressed at the level of the proximal tubule brush border membrane. Within 40 min of the initiation of the infusion the Na+-dependent phosphate uptake system in isolated membrane vesicles was decreased. Phosphate uptake in the absence of Na+, Na+-dependent D-glucose uptake, and 22Na+ uptake were not affected. These findings demonstrate the locus of this parathyroid hormone-independent adaptation and indicate the rapidity with which the membrane transport system is regulated.
AB - The sustained in vivo infusion of phosphate into thyroparathyroidectomized rats resulted, after 1 h, in a marked decrease in net phosphate reabsorption, even though the plasma concentration of phosphate continued to rise. This response to phosphate infusion was expressed at the level of the proximal tubule brush border membrane. Within 40 min of the initiation of the infusion the Na+-dependent phosphate uptake system in isolated membrane vesicles was decreased. Phosphate uptake in the absence of Na+, Na+-dependent D-glucose uptake, and 22Na+ uptake were not affected. These findings demonstrate the locus of this parathyroid hormone-independent adaptation and indicate the rapidity with which the membrane transport system is regulated.
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U2 - 10.1152/ajprenal.1984.246.4.f488
DO - 10.1152/ajprenal.1984.246.4.f488
M3 - Article
C2 - 6720903
AN - SCOPUS:0021416307
SN - 0363-6127
VL - 15
SP - F488-F494
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
IS - 4
ER -