TY - JOUR
T1 - Remitted depression and cognition in HIV
T2 - The role of cortisol and inflammation
AU - Rubin, Leah H.
AU - Langenecker, Scott A.
AU - Phan, K. Luan
AU - Keating, Sheila M.
AU - Neigh, Gretchen N.
AU - Weber, Kathleen M.
AU - Maki, Pauline M.
N1 - Funding Information:
Research reported in this publication was supported by the National Institute of Mental Health of the National Institutes of Health under Award Numbers K01MH098798 (Rubin), R21MH099978 (Rubin), R01MH113512 (Rubin), U54 AG062334, and R01MH110364. The project described was also supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR000050. This project was also supported in part by a University of Illinois at Chicago Campus Review Board (CRB) Grant (Rubin) and a Chicago Developmental Center for AIDS Research pilot grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We would like to thank Bruni Hirsch, Alana Aziz-Bradley, Jacob Ellis, Sheila D'Sa, Shannon Dowty, Lauren Drogos, Lacey Wisslead, Aleksa Anderson, and Preet Dhillon for their assistance with this study and Raha Dastgheyb for help with creating Figure 4. We would also like to thank Kathleen Weber and the CORE Center at John H. Stroger Jr Hospital of Cook County for help in recruiting participants to the present study. We would also like to thank all of our participants, for without you this work would not be possible.
Funding Information:
Research reported in this publication was supported by the National Institute of Mental Health of the National Institutes of Health under Award Numbers K01MH098798 (Rubin), R21MH099978 (Rubin), R01MH113512 (Rubin), U54 AG062334, and R01MH110364. The project described was also supported by the National Center for Advancing Translational Sciences , National Institutes of Health , through Grant UL1TR000050 . This project was also supported in part by a University of Illinois at Chicago Campus Review Board (CRB) Grant (Rubin) and a Chicago Developmental Center for AIDS Research pilot grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We would like to thank Bruni Hirsch, Alana Aziz-Bradley, Jacob Ellis, Sheila D’Sa, Shannon Dowty, Lauren Drogos, Lacey Wisslead, Aleksa Anderson, and Preet Dhillon for their assistance with this study and Raha Dastgheyb for help with creating Figure 4. We would also like to thank Kathleen Weber and the CORE Center at John H. Stroger Jr Hospital of Cook County for help in recruiting participants to the present study. We would also like to thank all of our participants, for without you this work would not be possible.
Publisher Copyright:
© 2020
PY - 2020/4
Y1 - 2020/4
N2 - In major depressive disorder (MDD) and remitted MDD (rMDD) alterations in cortisol and inflammation are associated with cognitive difficulties, but these relationships have not been investigated in HIV. We used secondary data from a placebo-controlled, cross-over study of cognitive performance following a probe of the hypothalamic-pituitary-adrenal (HPA) axis (low dose hydrocortisone; LDH 10 mg) in 65 people with HIV (PWH; 36 women). Using placebo data, we examined sex-specific associations between two biomarkers – basal afternoon salivary cortisol and salivary inflammatory cytokines - cognition, and rMDD. Salivary cortisol and inflammatory biomarkers were sampled across the 5 -h study. The panel of inflammatory markers included interleukin (IL)-6, IL-8, IL-1β, tumor necrosis factor-(TNF)-α, CRP, interferon gamma-induced protein (IP-10), monocyte chemotactic protein (MCP)-1, monokine induced by interferon (MIG), matrix metalloproteinase MMP-9, and MMP-1. Learning, memory, attention/concentration, and executive function were assessed 30 min and 4 h after the placebo intervention; visuospatial ability was also assessed 30 min after the placebo intervention. For women but not men with HIV, basal cortisol concentrations were higher in rMDD versus noMDD groups, and related to poorer learning and memory. For men and women with HIV, basal inflammatory cytokines were higher in rMDD versus noMDD groups, but were negatively related to cognition independent of rMDD status. Cortisol and cytokines relate to cognition in PWH, but the associations depended on sex, rMDD status, and their interaction.
AB - In major depressive disorder (MDD) and remitted MDD (rMDD) alterations in cortisol and inflammation are associated with cognitive difficulties, but these relationships have not been investigated in HIV. We used secondary data from a placebo-controlled, cross-over study of cognitive performance following a probe of the hypothalamic-pituitary-adrenal (HPA) axis (low dose hydrocortisone; LDH 10 mg) in 65 people with HIV (PWH; 36 women). Using placebo data, we examined sex-specific associations between two biomarkers – basal afternoon salivary cortisol and salivary inflammatory cytokines - cognition, and rMDD. Salivary cortisol and inflammatory biomarkers were sampled across the 5 -h study. The panel of inflammatory markers included interleukin (IL)-6, IL-8, IL-1β, tumor necrosis factor-(TNF)-α, CRP, interferon gamma-induced protein (IP-10), monocyte chemotactic protein (MCP)-1, monokine induced by interferon (MIG), matrix metalloproteinase MMP-9, and MMP-1. Learning, memory, attention/concentration, and executive function were assessed 30 min and 4 h after the placebo intervention; visuospatial ability was also assessed 30 min after the placebo intervention. For women but not men with HIV, basal cortisol concentrations were higher in rMDD versus noMDD groups, and related to poorer learning and memory. For men and women with HIV, basal inflammatory cytokines were higher in rMDD versus noMDD groups, but were negatively related to cognition independent of rMDD status. Cortisol and cytokines relate to cognition in PWH, but the associations depended on sex, rMDD status, and their interaction.
KW - Cognition
KW - Cortisol
KW - Depression
KW - HIV
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85079244137&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079244137&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2020.104609
DO - 10.1016/j.psyneuen.2020.104609
M3 - Article
C2 - 32062371
AN - SCOPUS:85079244137
SN - 0306-4530
VL - 114
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
M1 - 104609
ER -