@article{b47e1d0f23af4616952bcff2dd56e675,
title = "Remembering the host in tuberculosis drug development",
abstract = "New therapeutics to augment current approaches and shorten treatment duration are of critical importance for combating tuberculosis (TB), especially those with novel mechanisms of action to counter the emergence of drug-resistant TB. Host-directed therapy (HDT) offers a novel strategy with mechanisms that include activating immune defense mechanisms or ameliorating tissue damage. These and related concepts will be discussed along with issues that emerged from the workshop organized by the Stop TB Working Group on New Drugs, held at the Gordon Research Conference for Tuberculosis Drug Development in Lucca, Italy in June 2017, titled “Strategic Discussion on Repurposing Drugs & Host Directed Therapies for TB.” In this review, we will highlight recent data regarding drugs, pathways, and concepts that are important for successful development of HDTs for TB.",
keywords = "Drug development, Host-directed therapy, Macrophage, Meningitis, Tuberculosis",
author = "Frank, {Daniel J.} and Horne, {David J.} and Dutta, {Noton K.} and Shaku, {Moagi Tube} and Rajhmun Madensein and Hawn, {Thomas R.} and Steyn, {Adrie J.C.} and Karakousis, {Petros C.} and Kana, {Bavesh Davandra} and Graeme Meintjes and Barbara Laughon and Zaid Tanvir",
note = "Funding Information: Financial support. B. D. K. was supported by funding from an International Early Career Scientist Award from the Howard Hughes Medical Institute, the South African National Research Foundation; the South African Medical Research Council with funds received from the National Department of Health; and the Bill and Melinda Gates Foundation. M. T. S. was supported by the South African National Research Foundation. T. R. H. was supported by National Institutes of Health (NIH) and the Bill and Melinda Gates Foundation. A. J. C. S. was supported by NIH and the South African Medical Research Council. G. M. was supported by the Wellcome Trust, the South African Research Chairs Initiative of the Department of Science and Technology, National Research Foundation of South Africa, and the South African Medical Research Council through its TB and HIV Collaborating Centres Programme with funds received from the National Department of Health. Publisher Copyright: {\textcopyright} The Author(s) 2019.",
year = "2019",
month = may,
day = "1",
doi = "10.1093/infdis/jiy712",
language = "English (US)",
volume = "219",
pages = "1518--1524",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",
}