Relief of fecal incontinence by sacral nerve stimulation linked to focal brain activation

Lilli Lundby, Arne Møller, Steen Buntzen, Klaus Krogh, Kim Vang, Albert Gjedde, Søren Laurberg

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: This study aimed to test the hypothesis that sacral nerve stimulation affects afferent vagal projections to the central nervous system associated with frontal cortex activation in patients with fecal incontinence. PATIENTS: Nine women and one man received temporary sacral nerve stimulation with permanent electrodes as a treatment for fecal incontinence. INTERVENTIONS: We used positron emission tomography to record indices of regional cerebral blood flow before and after 30 minutes of continuous stimulation. We repeated this procedure after 2 weeks of continued stimulation, before and 30 minutes after arrest of the stimulation. RESULTS: The initial stimulation activated a region of the contralateral frontal cortex that normally is active during focused attention. After 2 weeks of stimulation, this activation had been replaced by activity in parts of the ipsilateral caudate nucleus, a region of the brain thought to be specifically involved in learning and reward processing. CONCLUSIONS: Sacral nerve stimulation induces changes in cerebral activity consistent with an effect on afferent projections of the vagus. The initial activation of the frontal cortex may reflect focused attention, whereas the subsequent activation of the caudate nucleus may reflect recruitment of mechanisms involved in learning and reward processing. These changes may contribute to the improved continence, which is an acquired result of the stimulation.

Original languageEnglish (US)
Pages (from-to)318-323
Number of pages6
JournalDiseases of the Colon and Rectum
Volume54
Issue number3
DOIs
StatePublished - Mar 2011
Externally publishedYes

Fingerprint

Fecal Incontinence
Frontal Lobe
Caudate Nucleus
Reward
Cerebrovascular Circulation
Brain
Learning
Regional Blood Flow
Positron-Emission Tomography
Electrodes
Central Nervous System
Therapeutics

Keywords

  • Cerebral activation
  • Fecal incontinence
  • Positron emission tomography
  • Sacral nerve stimulation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lundby, L., Møller, A., Buntzen, S., Krogh, K., Vang, K., Gjedde, A., & Laurberg, S. (2011). Relief of fecal incontinence by sacral nerve stimulation linked to focal brain activation. Diseases of the Colon and Rectum, 54(3), 318-323. https://doi.org/10.1007/DCR.0b013e31820348ac

Relief of fecal incontinence by sacral nerve stimulation linked to focal brain activation. / Lundby, Lilli; Møller, Arne; Buntzen, Steen; Krogh, Klaus; Vang, Kim; Gjedde, Albert; Laurberg, Søren.

In: Diseases of the Colon and Rectum, Vol. 54, No. 3, 03.2011, p. 318-323.

Research output: Contribution to journalArticle

Lundby, L, Møller, A, Buntzen, S, Krogh, K, Vang, K, Gjedde, A & Laurberg, S 2011, 'Relief of fecal incontinence by sacral nerve stimulation linked to focal brain activation', Diseases of the Colon and Rectum, vol. 54, no. 3, pp. 318-323. https://doi.org/10.1007/DCR.0b013e31820348ac
Lundby, Lilli ; Møller, Arne ; Buntzen, Steen ; Krogh, Klaus ; Vang, Kim ; Gjedde, Albert ; Laurberg, Søren. / Relief of fecal incontinence by sacral nerve stimulation linked to focal brain activation. In: Diseases of the Colon and Rectum. 2011 ; Vol. 54, No. 3. pp. 318-323.
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