Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke

Lewis A. Wheaton; Federico Villagra; Daniel F. Hanley; Richard F. Macko; Larry W. Forrester

doi:10.1016/j.jns.2008.09.012

Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke

Lewis A. Wheaton, Federico Villagra, Daniel F. Hanley, Richard F. Macko, Larry W. Forrester

School of Medicine

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.

Original language	English (US)
Pages (from-to)	115-117
Number of pages	3
Journal	Journal of the Neurological Sciences
Volume	276
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2008.09.012
State	Published - Jan 15 2009

Keywords

Lower extremity
Paretic
Quadriceps
Reliability
Stroke
TMS

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.jns.2008.09.012

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title = "Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke",

abstract = "Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.",

keywords = "Lower extremity, Paretic, Quadriceps, Reliability, Stroke, TMS",

author = "Wheaton, {Lewis A.} and Federico Villagra and Hanley, {Daniel F.} and Macko, {Richard F.} and Forrester, {Larry W.}",

note = "Funding Information: Grant support: National Institutes of Health, NIA (P60AG 12583) University of Maryland Claude D. Pepper Older Americans Independence Center; the Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore Geriatrics Research, Education and Clinical Center (GRECC), and Rehabilitation Research & Development Exercise and Robotics Center of Excellence (B3390K); NINDS 1RO1 NS 24282-08; the France-Merrick Foundation, the Johns Hopkins GCRC (NCRR #MO1-00052) and the Eleanor Naylor Dana Charitable Trust. ",

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doi = "10.1016/j.jns.2008.09.012",

language = "English (US)",

volume = "276",

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T1 - Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke

AU - Wheaton, Lewis A.

AU - Villagra, Federico

AU - Hanley, Daniel F.

AU - Macko, Richard F.

AU - Forrester, Larry W.

N1 - Funding Information: Grant support: National Institutes of Health, NIA (P60AG 12583) University of Maryland Claude D. Pepper Older Americans Independence Center; the Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore Geriatrics Research, Education and Clinical Center (GRECC), and Rehabilitation Research & Development Exercise and Robotics Center of Excellence (B3390K); NINDS 1RO1 NS 24282-08; the France-Merrick Foundation, the Johns Hopkins GCRC (NCRR #MO1-00052) and the Eleanor Naylor Dana Charitable Trust.

PY - 2009/1/15

Y1 - 2009/1/15

N2 - Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.

AB - Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.

KW - Lower extremity

KW - Paretic

KW - Quadriceps

KW - Reliability

KW - Stroke

KW - TMS

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Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke

Abstract

Keywords

ASJC Scopus subject areas

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