Reliability of a spinal metastasis prognostic score to model 1-year survival

C. Rory Goodwin, Andrew J. Schoenfeld, Nancy A. Abu-Bonsrah, Tomas Garzon-Muvdi, Eric W. Sankey, Mitchel B. Harris, Daniel Sciubba

Research output: Contribution to journalArticle

Abstract

Background: Predicting survival after surgery for patients with metastatic spine disease can be challenging, with multiple variables that can influence a patient's overall survival. Predictive models have been developed to assist clinicians in providing a prognosis for patients. Recently, Ghori et al. reported a composite model taking into account a modified Bauer score, preoperative albumin, and ambulatory status of patients with spinal metastasis. Using an independent cohort, we sought to assess the reliability and validity of this composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine. Purpose: This study aimed to assess the reliability and validity of the Ghori et al. composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine, using an independent cohort. Study Design/Setting: A retrospective study was carried out. Patient Sample: The sample comprised 161 patients with spinal metastasis undergoing surgery. Outcome Measures: Patients' modified Bauer score, preoperative albumin, and ambulatory status were assessed. Methods: This study used a retrospective analysis of 161 patients with spinal metastasis who underwent surgical management from 2007 to 2013. The ability of this composite model to predict 1-year survival was compared with actual patient survival using multivariable logistic regression to control for confounders, as well as post-regression diagnostics. Results: Our analysis revealed significantly lower 1-year mortality among patients with higher composite scores as compared with those with lower scores. Strong associations between scores and survival were appreciated in unadjusted analysis. The final model was able to account for 80% of the variation in the 1-year survival, and there was no evidence of lack of fit. Conclusion: This study demonstrates, in an independent cohort of spinal metastases patients, that a composite model taking into account the ambulatory status, serum albumin, and modified Bauer score is able to better predict postoperative survival. These data serve to validate the use of this predictive model in determining the prognosis of patients with spinal metastasis.

Original languageEnglish (US)
JournalSpine Journal
DOIs
StateAccepted/In press - Jan 9 2016

Fingerprint

Neoplasm Metastasis
Survival
Spine
Reproducibility of Results
Albumins
Serum Albumin
Neoplasms
Retrospective Studies
Logistic Models
Regression Analysis
Outcome Assessment (Health Care)
Mortality

Keywords

  • Ambulatory status
  • Metastases
  • Modified Bauer score
  • Prognosis
  • Spine surgery
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Goodwin, C. R., Schoenfeld, A. J., Abu-Bonsrah, N. A., Garzon-Muvdi, T., Sankey, E. W., Harris, M. B., & Sciubba, D. (Accepted/In press). Reliability of a spinal metastasis prognostic score to model 1-year survival. Spine Journal. https://doi.org/10.1016/j.spinee.2016.04.008

Reliability of a spinal metastasis prognostic score to model 1-year survival. / Goodwin, C. Rory; Schoenfeld, Andrew J.; Abu-Bonsrah, Nancy A.; Garzon-Muvdi, Tomas; Sankey, Eric W.; Harris, Mitchel B.; Sciubba, Daniel.

In: Spine Journal, 09.01.2016.

Research output: Contribution to journalArticle

Goodwin, CR, Schoenfeld, AJ, Abu-Bonsrah, NA, Garzon-Muvdi, T, Sankey, EW, Harris, MB & Sciubba, D 2016, 'Reliability of a spinal metastasis prognostic score to model 1-year survival', Spine Journal. https://doi.org/10.1016/j.spinee.2016.04.008
Goodwin CR, Schoenfeld AJ, Abu-Bonsrah NA, Garzon-Muvdi T, Sankey EW, Harris MB et al. Reliability of a spinal metastasis prognostic score to model 1-year survival. Spine Journal. 2016 Jan 9. https://doi.org/10.1016/j.spinee.2016.04.008
Goodwin, C. Rory ; Schoenfeld, Andrew J. ; Abu-Bonsrah, Nancy A. ; Garzon-Muvdi, Tomas ; Sankey, Eric W. ; Harris, Mitchel B. ; Sciubba, Daniel. / Reliability of a spinal metastasis prognostic score to model 1-year survival. In: Spine Journal. 2016.
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abstract = "Background: Predicting survival after surgery for patients with metastatic spine disease can be challenging, with multiple variables that can influence a patient's overall survival. Predictive models have been developed to assist clinicians in providing a prognosis for patients. Recently, Ghori et al. reported a composite model taking into account a modified Bauer score, preoperative albumin, and ambulatory status of patients with spinal metastasis. Using an independent cohort, we sought to assess the reliability and validity of this composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine. Purpose: This study aimed to assess the reliability and validity of the Ghori et al. composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine, using an independent cohort. Study Design/Setting: A retrospective study was carried out. Patient Sample: The sample comprised 161 patients with spinal metastasis undergoing surgery. Outcome Measures: Patients' modified Bauer score, preoperative albumin, and ambulatory status were assessed. Methods: This study used a retrospective analysis of 161 patients with spinal metastasis who underwent surgical management from 2007 to 2013. The ability of this composite model to predict 1-year survival was compared with actual patient survival using multivariable logistic regression to control for confounders, as well as post-regression diagnostics. Results: Our analysis revealed significantly lower 1-year mortality among patients with higher composite scores as compared with those with lower scores. Strong associations between scores and survival were appreciated in unadjusted analysis. The final model was able to account for 80{\%} of the variation in the 1-year survival, and there was no evidence of lack of fit. Conclusion: This study demonstrates, in an independent cohort of spinal metastases patients, that a composite model taking into account the ambulatory status, serum albumin, and modified Bauer score is able to better predict postoperative survival. These data serve to validate the use of this predictive model in determining the prognosis of patients with spinal metastasis.",
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AU - Goodwin, C. Rory

AU - Schoenfeld, Andrew J.

AU - Abu-Bonsrah, Nancy A.

AU - Garzon-Muvdi, Tomas

AU - Sankey, Eric W.

AU - Harris, Mitchel B.

AU - Sciubba, Daniel

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N2 - Background: Predicting survival after surgery for patients with metastatic spine disease can be challenging, with multiple variables that can influence a patient's overall survival. Predictive models have been developed to assist clinicians in providing a prognosis for patients. Recently, Ghori et al. reported a composite model taking into account a modified Bauer score, preoperative albumin, and ambulatory status of patients with spinal metastasis. Using an independent cohort, we sought to assess the reliability and validity of this composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine. Purpose: This study aimed to assess the reliability and validity of the Ghori et al. composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine, using an independent cohort. Study Design/Setting: A retrospective study was carried out. Patient Sample: The sample comprised 161 patients with spinal metastasis undergoing surgery. Outcome Measures: Patients' modified Bauer score, preoperative albumin, and ambulatory status were assessed. Methods: This study used a retrospective analysis of 161 patients with spinal metastasis who underwent surgical management from 2007 to 2013. The ability of this composite model to predict 1-year survival was compared with actual patient survival using multivariable logistic regression to control for confounders, as well as post-regression diagnostics. Results: Our analysis revealed significantly lower 1-year mortality among patients with higher composite scores as compared with those with lower scores. Strong associations between scores and survival were appreciated in unadjusted analysis. The final model was able to account for 80% of the variation in the 1-year survival, and there was no evidence of lack of fit. Conclusion: This study demonstrates, in an independent cohort of spinal metastases patients, that a composite model taking into account the ambulatory status, serum albumin, and modified Bauer score is able to better predict postoperative survival. These data serve to validate the use of this predictive model in determining the prognosis of patients with spinal metastasis.

AB - Background: Predicting survival after surgery for patients with metastatic spine disease can be challenging, with multiple variables that can influence a patient's overall survival. Predictive models have been developed to assist clinicians in providing a prognosis for patients. Recently, Ghori et al. reported a composite model taking into account a modified Bauer score, preoperative albumin, and ambulatory status of patients with spinal metastasis. Using an independent cohort, we sought to assess the reliability and validity of this composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine. Purpose: This study aimed to assess the reliability and validity of the Ghori et al. composite model to predict 1-year survival in patients diagnosed with metastatic cancer to the spine, using an independent cohort. Study Design/Setting: A retrospective study was carried out. Patient Sample: The sample comprised 161 patients with spinal metastasis undergoing surgery. Outcome Measures: Patients' modified Bauer score, preoperative albumin, and ambulatory status were assessed. Methods: This study used a retrospective analysis of 161 patients with spinal metastasis who underwent surgical management from 2007 to 2013. The ability of this composite model to predict 1-year survival was compared with actual patient survival using multivariable logistic regression to control for confounders, as well as post-regression diagnostics. Results: Our analysis revealed significantly lower 1-year mortality among patients with higher composite scores as compared with those with lower scores. Strong associations between scores and survival were appreciated in unadjusted analysis. The final model was able to account for 80% of the variation in the 1-year survival, and there was no evidence of lack of fit. Conclusion: This study demonstrates, in an independent cohort of spinal metastases patients, that a composite model taking into account the ambulatory status, serum albumin, and modified Bauer score is able to better predict postoperative survival. These data serve to validate the use of this predictive model in determining the prognosis of patients with spinal metastasis.

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