TY - JOUR
T1 - Reliability and Validity of Nincds-Adrda Criteria for Alzheimer's Disease
T2 - The National Institute of Mental Health Genetics Initiative
AU - Blacker, Deborah
AU - Albert, Marilyn S.
AU - Bassett, Susan S.
AU - Rodney, C. P.
AU - Harrell, Lindy E.
AU - Folstein, Marshai F.
PY - 1994/12
Y1 - 1994/12
N2 - To assess interrater reliability and validity of NINCDS-ADRDA (National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association) criteria for Alzheimer's disease (AD). A multisite reliability and validity study in which clinicians from each site diagnosed 60 case summaries yielding a preconsensus estimate of reliability and validity. A consensus conference was conducted for each disagreement, leading to a postconsensus estimate of validity. The criterion standard was a diagnosis of AD by autopsy. Three academic medical centers. A convenience sample of 60 detailed case summaries, 40 with AD and 20 with other dementing disorders. The κ coefficient, sensitivity, and specificity. The κ coefficient for preconsensus agreement on a diagnosis of probable or possible AD vs non-AD was 0.51; the sensitivity of a diagnosis of probable or possible AD for a pathological diagnosis of AD was 0.81, and the specificity was 0.73. The postconsensus sensitivity was 0.83, and the specificity was 0.84. The results support the reliability and validity of NINCDS-ADRDA criteria and show that the consensus process may improve diagnostic accuracy. The cases are reviewed with a focus on the sources of diagnostic disagreements and errors and possible changes that might improve the accuracy of the criteria.
AB - To assess interrater reliability and validity of NINCDS-ADRDA (National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association) criteria for Alzheimer's disease (AD). A multisite reliability and validity study in which clinicians from each site diagnosed 60 case summaries yielding a preconsensus estimate of reliability and validity. A consensus conference was conducted for each disagreement, leading to a postconsensus estimate of validity. The criterion standard was a diagnosis of AD by autopsy. Three academic medical centers. A convenience sample of 60 detailed case summaries, 40 with AD and 20 with other dementing disorders. The κ coefficient, sensitivity, and specificity. The κ coefficient for preconsensus agreement on a diagnosis of probable or possible AD vs non-AD was 0.51; the sensitivity of a diagnosis of probable or possible AD for a pathological diagnosis of AD was 0.81, and the specificity was 0.73. The postconsensus sensitivity was 0.83, and the specificity was 0.84. The results support the reliability and validity of NINCDS-ADRDA criteria and show that the consensus process may improve diagnostic accuracy. The cases are reviewed with a focus on the sources of diagnostic disagreements and errors and possible changes that might improve the accuracy of the criteria.
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U2 - 10.1001/archneur.1994.00540240042014
DO - 10.1001/archneur.1994.00540240042014
M3 - Article
C2 - 7986174
AN - SCOPUS:0027961102
SN - 0003-9942
VL - 51
SP - 1198
EP - 1204
JO - Archives of neurology
JF - Archives of neurology
IS - 12
ER -