AUTHORS' SYNOPSIS: Acute metabolic acidosis was followed by a decrease in myocardial contractility in the heart-lung preparation. However, myocardial performance was not affected by acidosis in preparations previously treated with propranolol. It is proposed that the negative inotropic effect of metabolic acidosis was related to a decrease in response of the myocardium to circulating catecholamines and not to a direct depressing effect of acidosis upon the myocardium.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)