Relevance of beta receptor blockade to the negative inotropic effect induced by metabolic acidosis

Juan Carlos Marsiglia, Horacio E. Cingolani, Norberto C. Gonzalez

Research output: Contribution to journalArticle

Abstract

AUTHORS' SYNOPSIS: Acute metabolic acidosis was followed by a decrease in myocardial contractility in the heart-lung preparation. However, myocardial performance was not affected by acidosis in preparations previously treated with propranolol. It is proposed that the negative inotropic effect of metabolic acidosis was related to a decrease in response of the myocardium to circulating catecholamines and not to a direct depressing effect of acidosis upon the myocardium.

Original languageEnglish (US)
Pages (from-to)336-343
Number of pages8
JournalCardiovascular research
Volume7
Issue number3
DOIs
StatePublished - May 1973

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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