TY - JOUR
T1 - Relevance of beta receptor blockade to the negative inotropic effect induced by metabolic acidosis
AU - Marsiglia, Juan Carlos
AU - Cingolani, Horacio E.
AU - Gonzalez, Norberto C.
PY - 1973/5
Y1 - 1973/5
N2 - AUTHORS' SYNOPSIS: Acute metabolic acidosis was followed by a decrease in myocardial contractility in the heart-lung preparation. However, myocardial performance was not affected by acidosis in preparations previously treated with propranolol. It is proposed that the negative inotropic effect of metabolic acidosis was related to a decrease in response of the myocardium to circulating catecholamines and not to a direct depressing effect of acidosis upon the myocardium.
AB - AUTHORS' SYNOPSIS: Acute metabolic acidosis was followed by a decrease in myocardial contractility in the heart-lung preparation. However, myocardial performance was not affected by acidosis in preparations previously treated with propranolol. It is proposed that the negative inotropic effect of metabolic acidosis was related to a decrease in response of the myocardium to circulating catecholamines and not to a direct depressing effect of acidosis upon the myocardium.
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U2 - 10.1093/cvr/7.3.336
DO - 10.1093/cvr/7.3.336
M3 - Article
C2 - 4722931
AN - SCOPUS:0015877319
SN - 0008-6363
VL - 7
SP - 336
EP - 343
JO - Cardiovascular research
JF - Cardiovascular research
IS - 3
ER -