Release of slow-reacting substance of anaphylaxis in the rat: Polymorphonuclear leukocyte

Robert P. Orange, Martin D. Valentine, K. Frank Austen

Research output: Contribution to journalArticle

Abstract

The antigen-induced release of slow-reacting substance of anaphylaxis was studied in rats previously treated with different biological and pharmacological agents to deplete these animals of specific cellular elements. The polymorphonuclear leukocyte appears necessary as a crucial cell type for optimum release of the slowreacting substance of anaphylaxis, whereas the mast cell and lymphocyte are not required.

Original languageEnglish (US)
Pages (from-to)318-319
Number of pages2
JournalScience
Volume157
Issue number3786
DOIs
StatePublished - Jan 1 1967
Externally publishedYes

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