Relaxation of imprinted genes in human cancer

Shirley Rainier, Laura A. Johnson, Craig J. Dobry, April J. Ping, Paul E. Grundy, Andrew P Feinberg

Research output: Contribution to journalArticle

Abstract

Genomic imprinting, or parental allele-specific expression of genes, has been demonstrated at the molecular level in insects and mice1,2 but not in man. Imprinting as a potential mechanism of human disease is suggested by paternal uniparental disomy of 11p15 in Beckwith-Wiedemann syndrome3 and by maternal uniparental disomy of 15q11-12 in Prader-Willi syndrome4. Beckwith-Wiedemann syndrome is characterized by multiorgan over-growth and predisposition to embryonal tumours such as Wilms' tumour of the kidney5. A loss of heterozygosity of 11p15 is also frequently found in a wide variety of tumours, including Wilms' tumour and lung, bladder, ovarian, liver and breast cancers6-11; 11p15 also directly suppresses tumour growth in vitro12. Two genes in this band, H19 and insulin-like growth factor-II (IGF2) undergo reciprocal imprinting in the mouse, with maternal expression of H19 (ref. 13) and paternal expression of IGF2 (ref. 14). Here we find that both of these genes show monoallelic expression in human tissues and, as in mouse, H19 is expressed from the maternal allele and IGF2 from the paternal allele. In contrast, 69% of Wilms' tumours not undergoing loss of heterozygosity at 11p showed biallelic expression of one or both genes, suggesting that relaxation or loss of imprinting could represent a new epigenetic mutational mechanism in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)747-749
Number of pages3
JournalNature
Volume362
Issue number6422
StatePublished - 1993
Externally publishedYes

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Wilms Tumor
Uniparental Disomy
Loss of Heterozygosity
Alleles
Mothers
Beckwith-Wiedemann Syndrome
Genes
Genomic Imprinting
Neoplasms
Insulin-Like Growth Factor II
Growth
Epigenomics
Insects
Carcinogenesis
Urinary Bladder
Breast
Gene Expression
Lung
Liver

ASJC Scopus subject areas

  • General

Cite this

Rainier, S., Johnson, L. A., Dobry, C. J., Ping, A. J., Grundy, P. E., & Feinberg, A. P. (1993). Relaxation of imprinted genes in human cancer. Nature, 362(6422), 747-749.

Relaxation of imprinted genes in human cancer. / Rainier, Shirley; Johnson, Laura A.; Dobry, Craig J.; Ping, April J.; Grundy, Paul E.; Feinberg, Andrew P.

In: Nature, Vol. 362, No. 6422, 1993, p. 747-749.

Research output: Contribution to journalArticle

Rainier, S, Johnson, LA, Dobry, CJ, Ping, AJ, Grundy, PE & Feinberg, AP 1993, 'Relaxation of imprinted genes in human cancer', Nature, vol. 362, no. 6422, pp. 747-749.
Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE, Feinberg AP. Relaxation of imprinted genes in human cancer. Nature. 1993;362(6422):747-749.
Rainier, Shirley ; Johnson, Laura A. ; Dobry, Craig J. ; Ping, April J. ; Grundy, Paul E. ; Feinberg, Andrew P. / Relaxation of imprinted genes in human cancer. In: Nature. 1993 ; Vol. 362, No. 6422. pp. 747-749.
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