K+-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 μM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 μM) or the β-adrenoceptor antagonist propranolol (1 μM). The mechanism underlying the relaxant effects of benzodiazepines on K+-contracted uterine rings is still under study.
- Benzodiazepines (peripheral effects)
- PK 11195
- Ro 5-4864
- Uterine relaxation
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience