Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats

Marcelo G. Kazanietz; A. Belén Elgoyhen

doi:10.1016/0014-2999(90)90646-N

Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats

Marcelo G. Kazanietz, A. Belén Elgoyhen

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

K⁺-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 μM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABA_A antagonist bicuculline (10 μM) or the β-adrenoceptor antagonist propranolol (1 μM). The mechanism underlying the relaxant effects of benzodiazepines on K⁺-contracted uterine rings is still under study.

Original language	English (US)
Pages (from-to)	231-234
Number of pages	4
Journal	European Journal of Pharmacology
Volume	185
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(90)90646-N
State	Published - Aug 28 1990
Externally published	Yes

Keywords

Benzodiazepines (peripheral effects)
PK 11195
Ro 5-4864
Uterine relaxation

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(90)90646-N

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title = "Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats",

abstract = "K+-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 μM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 μM) or the β-adrenoceptor antagonist propranolol (1 μM). The mechanism underlying the relaxant effects of benzodiazepines on K+-contracted uterine rings is still under study.",

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AU - Kazanietz, Marcelo G.

AU - Elgoyhen, A. Belén

PY - 1990/8/28

Y1 - 1990/8/28

N2 - K+-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 μM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 μM) or the β-adrenoceptor antagonist propranolol (1 μM). The mechanism underlying the relaxant effects of benzodiazepines on K+-contracted uterine rings is still under study.

AB - K+-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 μM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 μM) or the β-adrenoceptor antagonist propranolol (1 μM). The mechanism underlying the relaxant effects of benzodiazepines on K+-contracted uterine rings is still under study.

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KW - Ro 5-4864

KW - Uterine relaxation

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Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats

Abstract

Keywords

ASJC Scopus subject areas

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