Relaxant effect of benzodiazepines on uterine rings isolated from estrogen-treated rats

Marcelo G. Kazanietz, A. Belén Elgoyhen

Research output: Contribution to journalArticlepeer-review

Abstract

K+-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 μM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 μM) or the β-adrenoceptor antagonist propranolol (1 μM). The mechanism underlying the relaxant effects of benzodiazepines on K+-contracted uterine rings is still under study.

Original languageEnglish (US)
Pages (from-to)231-234
Number of pages4
JournalEuropean Journal of Pharmacology
Volume185
Issue number2-3
DOIs
StatePublished - Aug 28 1990
Externally publishedYes

Keywords

  • Benzodiazepines (peripheral effects)
  • PK 11195
  • Ro 5-4864
  • Uterine relaxation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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