Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease

Bradley T. Hyman, Kristin Marzloff, Julia J. Wenniger, Ted M. Dawson, David S. Bredt, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO‐synthesizing neurons are, however, resistant to NO‐ and glutamate‐induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.

Original languageEnglish (US)
Pages (from-to)818-820
Number of pages3
JournalAnnals of neurology
Volume32
Issue number6
DOIs
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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