Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease

Bradley T. Hyman; Kristin Marzloff; Julia J. Wenniger; Ted M. Dawson; David S. Bredt; Solomon H. Snyder

doi:10.1002/ana.410320618

Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease

Bradley T. Hyman, Kristin Marzloff, Julia J. Wenniger, Ted M. Dawson, David S. Bredt, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Abstract

Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO‐synthesizing neurons are, however, resistant to NO‐ and glutamate‐induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.

Original language	English (US)
Pages (from-to)	818-820
Number of pages	3
Journal	Annals of neurology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1002/ana.410320618
State	Published - Dec 1992

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO‐synthesizing neurons are, however, resistant to NO‐ and glutamate‐induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.",

author = "Hyman, {Bradley T.} and Kristin Marzloff and Wenniger, {Julia J.} and Dawson, {Ted M.} and Bredt, {David S.} and Snyder, {Solomon H.}",

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AU - Marzloff, Kristin

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AU - Dawson, Ted M.

AU - Bredt, David S.

AU - Snyder, Solomon H.

PY - 1992/12

Y1 - 1992/12

N2 - Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO‐synthesizing neurons are, however, resistant to NO‐ and glutamate‐induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.

AB - Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO‐synthesizing neurons are, however, resistant to NO‐ and glutamate‐induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.

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Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease

Abstract

ASJC Scopus subject areas

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