Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease

Bradley T. Hyman, Kristin Marzloff, Julia J. Wenniger, Ted M Dawson, David S. Bredt, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO-synthesizing neurons are, however, resistant to NO- and glutamate-induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.

Original languageEnglish (US)
Pages (from-to)818-820
Number of pages3
JournalAnnals of Neurology
Volume32
Issue number6
StatePublished - Dec 1992

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Nitric Oxide Synthase
Hippocampus
Alzheimer Disease
Nitric Oxide
Neurons
Glutamic Acid
Neurotransmitter Agents
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

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Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease. / Hyman, Bradley T.; Marzloff, Kristin; Wenniger, Julia J.; Dawson, Ted M; Bredt, David S.; Snyder, Solomon H.

In: Annals of Neurology, Vol. 32, No. 6, 12.1992, p. 818-820.

Research output: Contribution to journalArticle

Hyman, Bradley T. ; Marzloff, Kristin ; Wenniger, Julia J. ; Dawson, Ted M ; Bredt, David S. ; Snyder, Solomon H. / Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease. In: Annals of Neurology. 1992 ; Vol. 32, No. 6. pp. 818-820.
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